A beveled tip sheath liquid interface for capillary electrophoresis-electrospray ionization-mass spectrometry

Electrophoresis
Mei-Chun TsengGuor-Rong Her

Abstract

A simple and durable sheath liquid interface for capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) has been developed. This interface utilized a beveled tip emitter and was found to be more sensitive than the conventional sheath liquid interface. The use of a beveled tip reduces the optimal flow rate and therefore decreases sample dilution. The interface utilized a 380 microm inner diameter and 400 microm outer diameter beveled tapered tip. Because of the large inner diameter and outer diameter of the tip, the interface is robust and can be easily implemented. The performance of this interface for CZE-ESI-MS and micelle electrokinetic capillary electrophoresis-electrospray-mass spectrometry, as demonstrated by the analysis of synthetic drugs and triazine mixtures, was significantly better than results obtained using a conventional sheath liquid interface.

Citations

Oct 15, 2013·Journal of the American Society for Mass Spectrometry·Ioan MargineanRyan T Kelly
Jan 27, 2005·Journal of Mass Spectrometry : JMS
Mar 19, 2005·Electrophoresis·Philippe Schmitt-Kopplin, Matthias Englmann
Mar 3, 2010·Electrophoresis·E Jane MaxwellDavid D Y Chen
Nov 30, 2005·Electrophoresis·Ewa Dabek-Zlotorzynska, Valbona Celo
Sep 21, 2018·Electrophoresis·Rawi RamautarGerhardus J de Jong
Sep 30, 2010·Analytical Chemistry·E Jane MaxwellDavid D Y Chen

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