A bicyclic unit reversal to stabilize the 12/14-helix in mixed homochiral oligoureas.

Chemical Communications : Chem Comm
Pierre MilbeoBaptiste Legrand

Abstract

The insertion of cyclic building blocks in oligoureas to stabilize or modulate the properties of the 12/14-helix was often fruitless. We herein propose a fully compatible highly constrained building block that could be incorporated into oligoureas to develop highly stable and functional oligoureas helices.

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