A bigger mouse? The rat genome unveiled

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
John M Hancock

Abstract

Rattus norvegicus is an important experimental organism and interesting to evolutionary biologists. The recently published draft rat genome sequence provides us with insights into both the rat's evolution and its physiology. We learn more about genome evolution and, in particular, the adaptive significance of gene family expansions and the evolution of rodent genomes, which appears to have decelerated since the divergence of mouse and rat. An important observation is that some regions of genomes, many in noncoding regions, show very high sequence conservation, while others show unexpectedly fast evolution. Both of these may be pointers to functional significance.

References

Sep 25, 1979·Nucleic Acids Research·M PechH G Zachau
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C I Wu, W H Li
Dec 1, 1995·Journal of Molecular Evolution·J M Hancock
Jan 23, 1999·American Journal of Human Genetics·J C Schimenti
Nov 11, 1999·Molecular Biology and Evolution·M M AlbàJ M Hancock
Jun 16, 2000·Genome Research·A M MallonS D Brown
Oct 29, 2000·Progress in Nucleic Acid Research and Molecular Biology·R P Bowater, R D Wells
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Mar 26, 2003·Human Molecular Genetics·Richard D EmesChris P Ponting
Jun 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Pavel Pevzner, Glenn Tesler
Aug 9, 2003·Science·Evan E Eichler, David Sankoff
Oct 4, 2003·Science·Emmanouil T DermitzakisStylianos E Antonarakis
Dec 6, 2003·Genome Research·Elliott H MarguliesEric D Green
Dec 18, 2003·The Journal of Physiology·Allen W CowleyHoward J Jacob
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Feb 14, 2004·Molecular Biology and Evolution·Robert Friedman, Austin L Hughes
Mar 16, 2004·Science·Haig H Kazazian
Apr 2, 2004·Nature·Richard A GibbsUNKNOWN Rat Genome Sequencing Project Consortium
May 8, 2004·Science·Gill BejeranoDavid Haussler
Jun 16, 2004·Current Opinion in Microbiology·Andreas MeinkeEszter Nagy

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Citations

Mar 14, 2007·FEBS Letters·Małgorzata AdamczykWojciech Bal
Apr 15, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nina K Popova
Nov 22, 2007·Physiological Genomics·K C WorleyR A Gibbs
Jul 26, 2019·Scientific Reports·Guadalupe Gómez-BaenaRobert J Beynon

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