A binocular approach to treating amblyopia: antisuppression therapy

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Robert F HessBenjamin Thompson

Abstract

We developed a binocular treatment for amblyopia based on antisuppression therapy. A novel procedure is outlined for measuring the extent to which the fixing eye suppresses the fellow amblyopic eye. We hypothesize that suppression renders a structurally binocular system, functionally monocular. We demonstrate using three strabismic amblyopes that information can be combined normally between their eyes under viewing conditions where suppression is reduced. Also, we show that prolonged periods of viewing (under the artificial conditions of stimuli of different contrast in each eye) during which information from the two eyes is combined leads to a strengthening of binocular vision in such cases and eventual combination of binocular information under natural viewing conditions (stimuli of the same contrast in each eye). Concomitant improvement in monocular acuity of the amblyopic eye occurs with this reduction in suppression and strengthening of binocular fusion. Furthermore, in each of the three cases, stereoscopic function is established. This provides the basis for a new treatment of amblyopia, one that is purely binocular and aimed at reducing suppression as a first step.

References

Mar 1, 1993·Ophthalmology·M EpelbaumJ L Dufier
Jan 1, 1996·Eye·F Sengpiel, C Blakemore
Apr 13, 2005·Archives of Ophthalmology·Mitchell M ScheimanUNKNOWN Pediatric Eye Disease Investigator Group
Oct 27, 2007·Investigative Ophthalmology & Visual Science·Daniel H BakerRobert F Hess
Jul 19, 2008·Current Biology : CB·Benjamin ThompsonRobert F Hess
Sep 24, 2008·Vision Research·B MansouriR F Hess

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Citations

Jul 17, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Daniel P SpiegelBenjamin Thompson
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jian Ding, Dennis M Levi
Dec 17, 2010·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Bruce J W EvansJewlsy E Mathews
Dec 17, 2010·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Ignacio Serrano-PedrazaJenny C A Read
Oct 11, 2011·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Andrew T AstlePaul V McGraw
Oct 4, 2011·Clinical Ophthalmology·Ali Rastegarpour
Dec 29, 2012·Journal of Visualized Experiments : JoVE·Joanna M BlackBenjamin Thompson
Jul 26, 2014·Eye·S L LiE E Birch
Oct 6, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Agnes M F Wong
Oct 6, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Benjamin Thompson
May 15, 2013·Brain Stimulation·Simon ClavagnierRobert F Hess
Sep 13, 2011·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Lucy K GoodmanBenjamin Thompson
Jan 15, 2014·Journal of Pediatric Ophthalmology and Strabismus·Nicola PescosolidoStefano Fazio
Jun 19, 2013·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Donald E Mitchell
Mar 15, 2012·Developmental Psychobiology·Benjamin ThompsonRobert F Hess
Mar 5, 2014·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Robert F HessDaniel H Baker
Feb 6, 2014·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Rajkumar Nallour RaveendranWilliam R Bobier
Feb 22, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Long ToJeremy R Cooperstock
Apr 14, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Makoto SasakiAkihiko Tawara
Feb 1, 2015·Vision Research·Dennis M LeviDaphne Bavelier
Feb 14, 2015·Vision Research·Jinrong LiBenjamin Thompson
Mar 10, 2015·Vision Research·Jingyun Wang
Jun 7, 2015·Vision Research·Deborah GiaschiDavid Regan
Apr 29, 2015·Vision Research·Indu VedamurthyDennis M Levi
Feb 26, 2014·Strabismus·B MansouriP Pearson
Aug 30, 2011·Strabismus·R F HessB Thompson
Feb 19, 2013·Current Biology : CB·Kevin R Duffy, Donald E Mitchell
Jul 4, 2012·Vision Research·Sathyasri NarasimhanDeborah E Giaschi
Mar 26, 2015·Journal of Cataract and Refractive Surgery·Jan A VenterBarrie M Collins
Oct 14, 2014·Frontiers in Integrative Neuroscience·Emmanuel Bui Quoc, Chantal Milleret
Jul 6, 2014·Frontiers in Psychology·Lisa M HammBenjamin Thompson
Oct 22, 2015·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Simone L LiEileen E Birch
Sep 13, 2013·Scientific Reports·Jiawei ZhouRobert F Hess
Jan 7, 2017·Brain Research·S Castaño-CastañoF Nieto-Escamez
Sep 1, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Susan R Barry, Bruce Bridgeman
Jul 1, 2017·The British Journal of Ophthalmology·David NewshamRichard A Harrad
Aug 12, 2015·The Cochrane Database of Systematic Reviews·Vijay TailorAnnegret Dahlmann-Noor
Jan 30, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Anna R O'Connor, Laurence P Tidbury
Feb 3, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Lisa AsperSieu Khuu
Jan 8, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Jinrong LiBenjamin S Thompson
Aug 19, 2014·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Robert F HessBenjamin Thompson

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