PMID: 9180212May 16, 1997Paper

A bioadaptive approach for experimental pain research in humans using laser-evoked brain potentials

Neuroscience Letters
T WeissW H R Miltner

Abstract

In order to find an experimental approach counteracting habituation in experimental pain research using short infrared laser stimulation in humans we developed a bioadaptive method based on subject's report on painfulness of stimulation (pain report; PR). After determination of the initial relationship between the energy of the laser stimulus and the corresponding PRs, the approach continuously adjusts the intensity of noxious stimuli so that PR is kept constant across time. Each difference between the PR evoked by the actual laser stimulus and the desired PR leads to an increase or decrease of the laser output energy value for the next stimulation with the desired PR proportional to the PR difference as well as to the slope of the initial correlation function between laser energy and corresponding PRs. This method has been applied in a study with nine volunteers. Results show that the approach leads to a constant PR by increasing the laser output energy by 0.01 mJ/s per mm2 on the average. Furthermore, an analysis of the laser-evoked brain potentials (LEPs) recorded from Cz was performed for the first and second half of stimuli. However, no significant changes in latencies or amplitudes of the main LEP components recorded at 2...Continue Reading

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Citations

Jul 28, 2005·Der Schmerz·T Weiss, W H R Miltner
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·Jürgen Lorenz, Luis Garcia-Larrea
Jan 1, 1999·Electroencephalography and Clinical Neurophysiology·B Bromm, J Lorenz
Oct 12, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E OpsommerL Plaghki
Sep 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Massimiliano ValerianiMichele Tinazzi
Mar 23, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J SpiegelR D Treede
Jun 6, 2012·Computational and Mathematical Methods in Medicine·Christoph SchmidtLutz Leistritz
Jun 16, 2015·European Journal of Pain : EJP·P HüllemannR Baron
Jan 30, 2016·Scientific Reports·Henning Matthias ReimannThoralf Niendorf
Oct 1, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Gabor CsifcsakWalter Paulus
Jan 26, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurJean-Paul Nguyen
May 30, 2013·European Journal of Pain : EJP·P HüllemannR Baron
May 21, 2014·European Journal of Pain : EJP·M FranzT Weiss
Apr 2, 2015·International Journal of Cardiology·Antonino Di FrancoCatello Vollono
May 24, 2008·NeuroImage·Thomas WeissWolfgang H R Miltner
Nov 19, 2002·Pain·Romanas PolianskisLars Arendt-Nielsen
Nov 1, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Dieter KleinböhlRupert Hölzl
Jun 28, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marina de TommasoPaolo Livrea
Dec 25, 2003·Anesthesia and Analgesia·Winfried MeissnerWolfgang H Miltner
Mar 26, 2005·European Heart Journal·Massimiliano ValerianiGaetano Antonio Lanza
May 5, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Alberto RaggiStefano F Cappa
Dec 6, 2014·Journal of Neurophysiology·Hazel WrightAndrej Stancak
Jan 24, 2012·Journal of Applied Physiology·Guillaume BouvierCapucine Morélot-Panzini

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