PMID: 9431527Feb 12, 1998Paper

A bioadhesive delivery system as an alternative to infiltration anesthesia

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
C P TawareP V Devarajan

Abstract

The aim of this study was to determine the feasibility of a novel saliva-activated bioadhesive drug delivery system of lidocaine hydrochloride as a viable alternative to infiltration anesthesia in dentistry. The study was carried out in three stages. First, the drug delivery system (DDS) was subjectively evaluated for adherence to the gingival mucosa and peak effect of anesthesia. In the second stage, a comparative subjective and objective evaluation of the DDS with a marketed topical gel preparation was carried out. Finally an open label, nonblinded clinical trial was carried out using the exodontia model. A total of 49 extractions were attempted in 41 patients. The effect of the following variables was investigated in the study: (1) jaw (maxillary and mandibular), (2) overall mobility, (3) position-notation of tooth (1, 2, 3, 4 ...). The positive extractions were statistically analyzed by the t test comparison of means of two independent variables. Subjective evaluation revealed that the DDS adheres to the gingiva within a minute and produces peak effect in 15 minutes. Comparative study revealed that the DDS produces greater depth of anesthesia than the marketed topical gel. Of 49 extractions attempted with the DDS, 40 were s...Continue Reading

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Citations

Oct 17, 2012·International Journal of Pharmaceutical Investigation·Gaurav TiwariSaurabh K Bannerjee
Sep 14, 2007·Journal of Clinical Periodontology·Jill L StoltenbergBryan S Michalowicz
Jan 19, 2008·Periodontology 2000·John G Meechan
Nov 20, 2002·Dental Clinics of North America·John G Meechan
Sep 19, 2015·Journal of the Indian Society of Pedodontics and Preventive Dentistry·Lara Anwar ShehabKusai Baroudi
Nov 24, 1999·Pain·K YamamuraT Nabeshima
Sep 11, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Haruhisa FukayamaMasahiro Umino
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Yotaro ArakawaMitsuru Hashida
Aug 25, 2016·Expert Opinion on Drug Delivery·Michelle Franz-MontanEneida de Paula
Sep 17, 2020·Journal of Dental Anesthesia and Pain Medicine·Krishnan PadmineeGnanabagyan J Trophimus
May 11, 2018·Journal of Dental Anesthesia and Pain Medicine·Zavattini Angelo, Charalambous Polyvios

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