PMID: 6585169Jan 1, 1983

A biochemical study of the phagocytic activities of tuftsin and its analogues

Annals of the New York Academy of Sciences
K HisatsuneH Ogawa

Abstract

The effects of tuftsin and one of its analogues (4 [lys]-tuftsin) on phagocytosis of Staphylococcus aureus and Candida albicans were investigated in mice and rabbits. Mice were intravenously or orally administered 1-25 mg of 4 [lys]-tuftsin per kg daily for 4 to 7 days. After the mice were further treated with cyclophosphamide, they were intravenously challenged with C. albicans. More than 50% of the mice infected with C. albicans were killed within 7 days, although only 20% to 40% of those infected with the same microbes after 4 [lys]-tuftsin treatment died. A combination of 4 [lys]-tuftsin and an antibiotic was found to be somewhat more effective than either one alone. Further, pretreatment with 4 [lys]-tuftsin depressed microbial growth in the kidneys of mice bearing S-180 tumors. Rabbit peritoneal macrophages and polymorphonuclear leukocytes were harvested by intraperitoneal injection of liquid paraffin and of glycogen solution, respectively. For in vitro study of phagocytosis, rabbit macrophages of polymorphonuclear leukocytes were incubated in Hanks solution together with S. aureus and the number of survivors was determined. Enhanced engulfing activity of macrophages and increased bactericidal activity of polymorphonuclea...Continue Reading

References

May 1, 1985·The Veterinary Clinics of North America. Small Animal Practice·E G MacEwen

Citations

Jul 1, 1978·The Journal of Experimental Medicine·R B JohnstonZ A Cohn
Jan 1, 1977·International Journal of Peptide and Protein Research·D KonopínskaE Klonowska
Jan 1, 1978·Microbiology and Immunology·K HisatsuneI Muramatsu
Nov 14, 1970·Nature·V A Najjar, K Nishioka
Apr 14, 1972·Biochemical and Biophysical Research Communications·K NishiokaV A Najjar
Apr 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·B V Fidalgo, V A Najjar
Mar 1, 1973·The Journal of Clinical Investigation·B M BabiorJ T Curnutte
Mar 28, 1974·The New England Journal of Medicine·T P Stossel
Dec 4, 1981·Molecular and Cellular Biochemistry·J Martinez, F Winternitz
Dec 4, 1981·Molecular and Cellular Biochemistry·K NishiokaR D Noyes

Related Concepts

Macrophages, Peritoneal
Neutrophil Band Cells
Candida albicans
Cyclophosphamide
Cyclodictyon albicans
Daiotyla albicans
Thymidine
Spleen
Depressed - Symptom
Cineraria albicans

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