A biodegradable block polyurethane nerve-guidance scaffold enhancing rapid vascularization and promoting reconstruction of transected sciatic nerve in Sprague-Dawley rats.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Yuqing Niu, Massimiliano Galluzzi

Abstract

Reconstruction of peripheral nerve defects with tissue engineered nerve scaffolds is an exciting field of biomedical research and holds potential for clinical application. However, due to poor neovascularization after the implantation, nerve regeneration is still not satisfactory, especially for large nerve defects. These obstacles hinder the investigation of basic neurobiological principles and development of a wide range of treatments for peripheral nerve diseases. Herein, we designed an amphiphilic alternating block polyurethane (abbreviated as PU) copolymer-based nerve guidance scaffold, which has good Schwann cell compatibility, and more importantly, a rapid vascularization of the scaffold in vivo. In the sciatic nerve transection model of SD rats, vascularized PU nerve guidance scaffolds induced rapid regeneration of nerve fibers and axons along the scaffold. Through the analysis of nerve electrophysiology, sciatic nerve functional index, histology, and immunofluorescence related to angiogenesis, we determined that PU with rapid vascularization function enhances recovery and re-obtains nerve conduction function. Our study points out a new strategy of using nerve tissue engineering scaffolds to treat large nerve defects.

References

Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J D SchmelzerP A Low
Feb 11, 2000·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·S GeunaR Guglielmone
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Aug 5, 2008·Tissue Engineering. Part B, Reviews·Franklin Rivera Bueno, Sameer B Shah
Apr 8, 2009·Experimental Neurology·Wilson Z Ray, Susan E Mackinnon
Aug 18, 2009·International Review of Neurobiology·Stefania RaimondoStefano Geuna
Jul 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit PabariAlexander M Seifalian
Sep 11, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Xiaoduo ZhanWutian Wu
Jan 11, 2013·Journal of Reconstructive Microsurgery·P Konofaos, J P Ver Halen
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Guangyao LiKaitian Xu
May 15, 2013·Nature Biotechnology·Lei ZhangShaoyi Jiang
Nov 13, 2013·Nature Reviews. Neurology·Jami Scheib, Ahmet Höke
May 14, 2014·Biomaterials·Xiaosong GuDavid F Williams
Nov 25, 2014·Journal of the Peripheral Nervous System : JPNS·Giulia RonchiStefano Geuna
Dec 3, 2014·Advanced Drug Delivery Reviews·Alessandro FaroniAdam J Reid
Jul 30, 2015·Biomaterials Science·H M RostamA M Ghaemmaghami
Aug 27, 2015·The European Journal of Neuroscience·S GeunaC Grothe
Apr 14, 2016·Annals of Biomedical Engineering·Vivian K Lee, Guohao Dai
Sep 8, 2016·Advanced Healthcare Materials·Ana C PinhoJorge F J Coelho
May 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Richard P Mann, Dirk Helbing
Jul 18, 2017·Advanced Drug Delivery Reviews·Liam ChungJennifer H Elisseeff
Feb 17, 2018·ACS Applied Materials & Interfaces·Cancan XuYi Hong
May 29, 2018·Colloids and Surfaces. B, Biointerfaces·Jing WangXiumei Mo
Aug 24, 2018·Advanced Materials·Qingmeng PiYu Shrike Zhang
Jul 31, 2019·Biomaterials Science·A AlessandrinoG Freddi
Feb 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chengbin XueXiaosong Gu
Aug 19, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Aida NaghilouChristine Radtke

❮ Previous
Next ❯

Citations

Oct 20, 2021·ACS Applied Materials & Interfaces·Junjie ShenXianyou Zheng

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
transmission electron microscopy
PCL

Software Mentioned

GraphPad Prism
ARRIVE
ImageJ
Labview

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Biological Regulators and Homeostatic Agents
X Y HongW T Yin
Journal of Biological Regulators and Homeostatic Agents
X Y HongW T Yin
Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
Silviu Adrian MarinescuRuxandra Diana Sinescu
© 2021 Meta ULC. All rights reserved