A biodegradable perivascular wrap for controlled, local and directed drug delivery.

Journal of Controlled Release : Official Journal of the Controlled Release Society
William G SandersChristi M Terry

Abstract

Perivascular delivery of anti-proliferative agents is an attractive approach to inhibit hyperplasia that causes stenosis of synthetic hemodialysis grafts and other vascular grafts. Perivascular drug delivery systems typically release drugs to both the vascular wall and non-target extravascular tissue. The objective of this study was to develop a biodegradable, perivascular delivery system for localized, sustained and unidirectional drug release in the context of synthetic arteriovenous (AV) grafts used for chronic hemodialysis. To this end, a dense non-porous polymer barrier layer was laminated to either i) a drug-loaded non-porous polymer layer or ii) a porous polymer layer. To provide tunability, the porous layer could be loaded with drug during casting or later infused with a drug-loaded hydrogel. The polymer bilayer wraps were prepared by a solvent casting, thermal-phase inversion technique using either polylactide-co-glycolide (PLGA) or polycaprolactone (PCL). Sunitinib, a multi-target receptor tyrosine kinase inhibitor, was used as a model drug. In a modified transwell chamber system, the barrier function of the non-porous PLGA backing was superior to the non-porous PCL backing although both markedly inhibited drug diffus...Continue Reading

References

Nov 1, 1990·The Journal of Cell Biology·M W MajeskyS M Schwartz
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E R EdelmanM J Karnovsky
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·M MiyajimaM Ikeda
Apr 1, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·D D HileM V Pishko
Feb 24, 2001·Journal of Vascular and Interventional Radiology : JVIR·P E SignoreB M McManus
Apr 28, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M F WeissJ M Anderson
Sep 5, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·D L ElbertJ A Hubbell
Mar 19, 2002·American Journal of Preventive Medicine·Louise B Russell, Nancy Wolff
Jun 6, 2003·Kidney International·Sunanda J RamWilliam D Paulson
Dec 4, 2003·Biomaterials·Xiao Zheng ShuGlenn D Prestwich
Sep 15, 2004·International Journal of Pharmaceutics·John K JacksonHelen M Burt
Mar 15, 2005·Biomaterials·Yanchun LiuGlenn D Prestwich
Jul 9, 2005·Journal of Biomaterials Science. Polymer Edition·A SantoveñaJ B Fariña
Dec 2, 2005·Pharmaceutical Research·Sridhar DuvvuriAshim K Mitra
Jul 1, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Tracey A DechertDorne R Yager
Jul 11, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Burnett KellyPrabir Roy-Chaudhury
Jul 3, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Li LiAlfred K Cheung
Aug 11, 2007·Nature Reviews. Drug Discovery·Sandrine FaivreEric Raymond
Aug 12, 2008·Current Pharmaceutical Biotechnology·Glenn D Prestwich, Jing-Wen Kuo
Oct 1, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Patton MinkinSharyn D Baker
May 12, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shawn C OwenChristi M Terry
May 21, 2010·The New England Journal of Medicine·Jan Malik, Vladimir Tuka
Jun 23, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei LeiLing Tian
Jul 28, 2010·Journal of Biomaterials Applications·Joanne Manson, Dorian Dixon
Jan 12, 2011·Journal of Materials Science. Materials in Medicine·Xi LiuKe-Min Chen
Mar 12, 2011·Advanced Materials·Jason A Burdick, Glenn D Prestwich
Jan 14, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·William D PaulsonSriram S Iyer

❮ Previous
Next ❯

Citations

Jul 16, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kang Ju LeeWonHyoung Ryu
Nov 6, 2014·Advances in Wound Care·Barbara WirostkoGlenn D Prestwich
Apr 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ioanna MylonakiFlorence Delie
Dec 4, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chang Kuk ChoiWonHyoung Ryu
May 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mirnal A ChaudharyK Craig Kent
Aug 11, 2016·Journal of Biomedical Materials Research. Part a·Kevin D LanceMichael S Conte
Sep 28, 2016·Macromolecular Rapid Communications·Timothy C BoireHak-Joon Sung
Nov 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Christi M Terry, Laura M Dember
Dec 12, 2017·Biomedical Materials·Meenasree BukkaMukty Sinha
Jun 18, 2017·AAPS PharmSciTech·Saad M AlshahraniFaiyaz Shakeel
Apr 5, 2018·Interactive Cardiovascular and Thoracic Surgery·Ioanna MylonakiFrançois Saucy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
William D PaulsonSriram S Iyer
Journal of Controlled Release : Official Journal of the Controlled Release Society
Jung-Hwan ParkMark R Prausnitz
Journal of Polymer Science. Part B, Polymer Physics
Bret D UleryCato T Laurencin
© 2021 Meta ULC. All rights reserved