A bioenergetics systems evaluation of ketogenic diet liver effects

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Lewis J HutflesRussell H Swerdlow

Abstract

Ketogenic diets induce hepatocyte fatty acid oxidation and ketone body production. To further evaluate how ketogenic diets affect hepatocyte bioenergetic infrastructure, we analyzed livers from C57Bl/6J male mice maintained for 1 month on a ketogenic or standard chow diet. Compared with the standard diet, the ketogenic diet increased cytosolic and mitochondrial protein acetylation and also altered protein succinylation patterns. SIRT3 protein decreased while SIRT5 protein increased, and gluconeogenesis, oxidative phosphorylation, and mitochondrial biogenesis pathway proteins were variably and likely strategically altered. The pattern of changes observed can be used to inform a broader systems overview of how ketogenic diets affect liver bioenergetics.

References

May 1, 1969·The Biochemical Journal·H A KrebsR A Freedland
Feb 15, 2007·American Journal of Physiology. Endocrinology and Metabolism·Adam R KennedyEleftheria Maratos-Flier
Aug 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hirokazu FukuiCarlos T Moraes
May 27, 2008·Journal of the International Society of Sports Nutrition·Anssi H Manninen
Dec 31, 2009·PloS One·David N RuskinSusan A Masino
Sep 3, 2010·American Journal of Physiology. Endocrinology and Metabolism·François R JornayvazGerald I Shulman
Mar 5, 2011·Epilepsia·Sharon S McDanielMichael Wong
Dec 14, 2011·IUBMB Life·Andrew P Halestrap, Marieangela C Wilson
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Matthew J RardinBradford W Gibson
Jun 29, 2013·Molecular Cell·Jeongsoon ParkYingming Zhao
Sep 6, 2013·British Journal of Pharmacology·Russell H Swerdlow
Oct 22, 2013·Trends in Endocrinology and Metabolism : TEM·John C Newman, Eric Verdin
Dec 10, 2013·Cell Metabolism·Matthew J RardinEric Verdin
Aug 12, 2014·Journal of Bioenergetics and Biomembranes·J Eva SelfridgeRussell H Swerdlow
May 27, 2015·Epilepsia·Nina DupuisStéphane Auvin
Jul 15, 2015·Biochimica Et Biophysica Acta·Nicholas DourisEleftheria Maratos-Flier
Jul 1, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Angelia Maleah HollandMichael D Roberts
Feb 9, 2017·Cell Metabolism·Patrycja Puchalska, Peter A Crawford

❮ Previous
Next ❯

Citations

May 23, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mary P MooreR Scott Rector
Aug 8, 2019·Medicine and Science in Sports and Exercise·Tai-Yu HuangRobert C Noland
Feb 9, 2020·The International Journal of Neuropsychopharmacology·Gerwyn MorrisLisa Olive
Jul 22, 2018·Neurochemical Research·Md Mahdi Hasan-OliveLinda H Bergersen
Apr 4, 2021·International Journal of Molecular Sciences·Guglielmina ChimientiFrancesco Russo
Apr 13, 2021·American Journal of Physiology. Endocrinology and Metabolism·Tai-Yu HuangRobert C Noland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Handbook of Clinical Neurology
Roberto H Caraballo, E P Vining
Archives of Disease in Childhood
R W Ellis
Developmental Medicine and Child Neurology
Eric H Kossoff
Journal of Human Nutrition
JAMA : the Journal of the American Medical Association
Zhaoping Li, David Heber
© 2022 Meta ULC. All rights reserved