A bioengineered nisin derivative to control biofilms of Staphylococcus pseudintermedius

PloS One
Des FieldR Paul Ross

Abstract

Antibiotic resistance and the shortage of novel antimicrobials are among the biggest challenges facing society. One of the major factors contributing to resistance is the use of frontline clinical antibiotics in veterinary practice. In order to properly manage dwindling antibiotic resources, we must identify antimicrobials that are specifically targeted to veterinary applications. Nisin is a member of the lantibiotic family of antimicrobial peptides that exhibit potent antibacterial activity against many gram-positive bacteria, including human and animal pathogens such as Staphylococcus, Bacillus, Listeria, and Clostridium. Although not currently used in human medicine, nisin is already employed commercially as an anti-mastitis product in the veterinary field. Recently we have used bioengineering strategies to enhance the activity of nisin against several high profile targets, including multi-drug resistant clinical pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) and also against staphylococci and streptococci associated with bovine mastitis. However, newly emerging pathogens such as methicillin resistant Staphylococcus pseudintermedius (MRSP) pose a significant th...Continue Reading

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Citations

Dec 8, 2015·Frontiers in Microbiology·Des FieldR P Ross
Jun 4, 2016·Antonie van Leeuwenhoek·Luana Martins PerinLuís Augusto Nero
Nov 3, 2016·Frontiers in Microbiology·Laura M CoughlanAvelino Alvarez-Ordóñez
Nov 12, 2016·Frontiers in Microbiology·Des FieldColin Hill
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May 1, 2018·NPJ Biofilms and Microbiomes·Harsh MathurR Paul Ross
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Jul 14, 2020·Veterinary Research Communications·Laureano SchofsSergio F Sánchez Bruni
May 6, 2017·Frontiers in Microbiology·Harsh MathurR Paul Ross
Aug 21, 2019·Frontiers in Microbiology·Shilja ChoyamRajagopal Kammara
Feb 10, 2021·Pathogens·Angela FrançaLuís D R Melo
Jan 18, 2021·International Journal of Biological Macromolecules·Xiangxiang WangMingqiang Qiao
Mar 11, 2021·Critical Reviews in Microbiology·Ana Andréa Teixeira BarbosaSilvio Santana Dolabella
May 18, 2021·Frontiers in Molecular Biosciences·Lauren WalshR Paul Ross
Jul 15, 2021·International Journal of Microbiology·Ellen TwomeyMáire Begley

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Datasets Mentioned

BETA
GM17

Methods Mentioned

BETA
PCR

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