A bioinformatic survey of distribution, conservation, and probable functions of LuxR solo regulators in bacteria

Frontiers in Cellular and Infection Microbiology
Sujatha SubramoniZulma R Suárez-Moreno

Abstract

LuxR solo transcriptional regulators contain both an autoinducer binding domain (ABD; N-terminal) and a DNA binding Helix-Turn-Helix domain (HTH; C-terminal), but are not associated with a cognate N-acyl homoserine lactone (AHL) synthase coding gene in the same genome. Although a few LuxR solos have been characterized, their distributions as well as their role in bacterial signal perception and other processes are poorly understood. In this study we have carried out a systematic survey of distribution of all ABD containing LuxR transcriptional regulators (QS domain LuxRs) available in the InterPro database (IPR005143), and identified those lacking a cognate AHL synthase. These LuxR solos were then analyzed regarding their taxonomical distribution, predicted functions of neighboring genes and the presence of complete AHL-QS systems in the genomes that carry them. Our analyses reveal the presence of one or multiple predicted LuxR solos in many proteobacterial genomes carrying QS domain LuxRs, some of them harboring genes for one or more AHL-QS circuits. The presence of LuxR solos in bacteria occupying diverse environments suggests potential ecological functions for these proteins beyond AHL and interkingdom signaling. Based on ge...Continue Reading

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Citations

Dec 10, 2015·Frontiers in Cellular and Infection Microbiology·Vittorio Venturi, Brian M M Ahmer
Apr 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bei GaoKun Lu
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Apr 2, 2021·MSphere·Cristina BezVittorio Venturi
Jan 7, 2022·Journal of Agricultural and Food Chemistry·Qingying FanYang Wang

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Datasets Mentioned

BETA
IPR005143
AAC44036.1
ATCC31532
AAP32919.1
UPB0736
CBI67623.1
AEH78836.1
ES114
AAA27542.1
AAZ50597.1

Software Mentioned

BioNJ
MEGA
RSAT
BPROM
CLANS
Microsoft Office
Excel
SynTax
FGENESB
MEME

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