A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

Advanced Materials
Di WuYunfeng Lu

Abstract

Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by the blood-brain barrier (BBB) that impedes the access of most therapeutics to the brain. A CNS delivery platform for protein therapeutics, which is achieved by encapsulating the proteins within nanocapsules that contain choline and acetylcholine analogues, is reported herein. Mediated by nicotinic acetylcholine receptors and choline transporters, such nanocapsules can effectively penetrate the BBB and deliver the therapeutics to the CNS, as demonstrated in mice and non-human primates. This universal platform, in general, enables the delivery of any protein therapeutics of interest to the brain, opening a new avenue for the treatment of CNS diseases.

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Citations

Jul 4, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Haotian SunChong Cheng
Sep 11, 2019·Nature Biomedical Engineering·Reina Bendayan
Sep 15, 2020·Advanced Materials·Meng QinYunfeng Lu
Jun 21, 2020·Angewandte Chemie·Xudong LiLichen Yin
Dec 15, 2020·Biological Reviews of the Cambridge Philosophical Society·Zhe ShiXin-Min Liu
Jan 29, 2021·Macromolecular Bioscience·Jiamin BanXubo Yuan
Nov 17, 2020·International Journal of Nanomedicine·Alicja KarabaszKrzysztof Szczepanowicz
Nov 20, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Junha LimWon Jong Kim
Jul 22, 2021·Journal of the American Chemical Society·Ke XueBen Zhong Tang
Jul 2, 2021·Advanced Materials·Meng LiPeng Huang

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