A biomarker approach to assessing xenobiotic exposure in Atlantic tomcod from the North American Atlantic coast

Environmental Health Perspectives
I I WirginJ E Stein

Abstract

We determined levels of hepatic cytochrome P4501A (CYP1A) mRNA, hepatic DNA adducts, and fluorescent aromatic compounds (FACs) in bile, a measure of exposure to polyaromatic hydrocarbons, in Atlantic tomcod from six river systems ranging from highly polluted to relatively pristine on the northeast North American coast (the Hudson River, New York; the St. Lawrence River, Quebec; the Miramichi River, New Brunswick; the Saco and Royal rivers, Maine; and the Margaree River, Nova Scotia). Hudson River tomcod showed the greatest response for all parameters, and tomcod from the Margaree River exhibited the least response. Tomcod from the Miramichi River exhibited marked induction of CYP1A mRNA but low levels of hepatic DNA adducts and biliary FACs, whereas fish from the St. Lawrence River showed no induction of CYP1A mRNA and moderately elevated levels of DNA adducts and biliary FACs. In tomcod from the Hudson and Miramichi rivers, the levels of CYP1A mRNA were 28 times and 14 times, respectively, as great as the levels in fish from the St. Lawrence, Saco/Royal, and Margaree rivers. Mean levels of DNA adducts varied from 120 nmol adducts/mol bases in Hudson River tomcod to < 3 nmol adducts/mol bases in fish from the Miramichi and Marg...Continue Reading

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Jun 1, 1991·Environmental Research·G L KreamerI Wirgin
Jan 1, 1991·Environmental Health Perspectives·U Varanasi, J E Stein
May 1, 1990·The Science of the Total Environment·J C Harshbarger, J B Clark
Dec 1, 1981·Bulletin of Environmental Contamination and Toxicology·R J KlaudaG K Rice
Dec 1, 1994·Environmental Health Perspectives·J E SteinU Varanasi

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Citations

Feb 1, 1997·Environmental Health Perspectives·G A LeBlanc, L J Bain
Jan 6, 2006·Environmental Health Perspectives·Zhanpeng YuanIsaac Wirgin
Jul 22, 1998·Mutation Research·I Wirgin, J R Waldman
Nov 30, 2012·Environmental Science and Pollution Research International·Célie DupuyMichel Fournier
Jul 10, 2002·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Nirmal K RoyIsaac Wirgin
Aug 24, 2000·Critical Reviews in Toxicology·J J WhyteD E Tillitt
Aug 15, 1997·Archives of Biochemistry and Biophysics·N K Roy, I Wirgin

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