A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis

Journal of Internal Medicine
Signe Holm NielsenIsabel Gonçalves

Abstract

Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-mediated COL1 biomarker, C1M, was associated with cardiovascular events, cardiovascular mortality and all-cause mortality in a large prospective cohort of patients with known atherosclerosis. Serum from 787 patients who underwent a carotid endarterectomy was included. Circulating levels of C1M were measured in serum. A total of 473 patients were followed for 6 years after surgery. Associations between C1M and incidence of cardiovascular events, cardiovascular mortality and all-cause mortality were assessed by Kaplan-Meier curves and Cox regression analysis. A total of 101 (21.4%) patients suffered from nonfatal cardiovascular events during the follow-up period, and 64 (13.5%) patients died. Of these, 39 (60.9%) died from cardiovascular diseases. Patients with C1M levels above the median were significantly associated with cardiovascular events, cardiovascular mortality and all-cause mortality (P < 0.001, P = 0.004 and P < 0.001...Continue Reading

References

Apr 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S KatsudaI Nakanishi
Apr 17, 2002·Journal of the American College of Cardiology·Jing WangWard Casscells
Jun 9, 2006·Cardiovascular Research·Jason L JohnsonChristopher L Jackson
Aug 5, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Salman ChoudharyJoel D Morrisett
Apr 3, 2007·Journal of the American College of Cardiology·Seemantini K NadkarniGuillermo J Tearney
Jan 16, 2009·Vascular Medicine·Eser AdiguzelMichelle P Bendeck
May 5, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael SchäfersSven Hermann
Oct 13, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Dj LeemingMa Karsdal
Jul 19, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Andreas EdsfeldtJan Nilsson
Aug 20, 2014·Current Opinion in Lipidology·Annelie ShamiAnna Hultgårdh-Nilsson
Jan 27, 2016·Circulation·Laxmi S MehtaUNKNOWN American Heart Association Cardiovascular Disease in Women and Special Populations Committee of the Council on Clinical Card
Sep 13, 2017·European Journal of Pharmacology·Jason L Johnson

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Citations

Jan 10, 2021·Journal of Cardiovascular Translational Research·Rohit MohindraFinosh G Thankam

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