A biomechanical and histological evaluation of the structure and function of the healing medial collateral ligament in a goat model

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
S D AbramowitchSavio L-Y Woo

Abstract

This study evaluated the healing process of an isolated medial collateral ligament (MCL) rupture at 12 weeks in a goat model. Using a robotic/UFS testing system, knee kinematics in multiple degrees of freedom and in situ forces in the healing MCL in response to (1) a 67-N anterior tibial load and (2) a 5-Nm valgus moment were evaluated as a function of angles of knee flexion. Then a uniaxial tensile test of femur-MCL-tibia complexes (FMTCs) was preformed to obtain the structural properties of the FMTC and mechanical properties of the healing MCL substance. The histological appearance of the healing MCL was also examined for collagen and cell organization. The anterior tibial translation in response to a 67-N anterior tibial load was found to range from 1.9 to 2.4 mm, which was not significantly different from the sham-operated, contralateral control knee. In response to a 5-Nm valgus moment, however, MCL injury caused a 40% or more increase in valgus rotations over sham-operated controls for all angles of knee flexion tested. The magnitudes of the in situ forces in the healing MCLs for neither external loading conditions differed from sham-operated controls. For the structural properties of the healing FMTC, the stiffness retur...Continue Reading

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Citations

May 22, 2009·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Ho-Joong JungSavio L-Y Woo
Oct 30, 2004·Connective Tissue Research·Yvo GijssenLeendert Blankevoort
Nov 16, 2013·Journal of Biomechanical Engineering·Shawn P Reese, Jeffrey A Weiss
Sep 7, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wei-Hsiu HsuPey-Jium Chang
Jul 2, 2016·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Chao WanShizhu Wen
Aug 26, 2006·Biomechanics and Modeling in Mechanobiology·Raffaella De Vita, William S Slaughter
Aug 11, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Natasha AnokaDavid N M Caborn
May 25, 2010·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Shan-Ling HsuSavio Ly Woo
Mar 17, 2020·The American Journal of Sports Medicine·Dhong Won LeeSeung Ik Cho
Sep 27, 2019·American Journal of Veterinary Research·Kylie A LeggChris W Rogers
Dec 22, 2020·Regenerative Engineering and Translational Medicine·Mohammed A BarajaaCato T Laurencin

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