A biomechanical model of agonist-initiated contraction in the asthmatic airway.

Respiratory Physiology & Neurobiology
B S BrookO E Jensen

Abstract

This paper presents a modelling framework in which the local stress environment of airway smooth muscle (ASM) cells may be predicted and cellular responses to local stress may be investigated. We consider an elastic axisymmetric model of a layer of connective tissue and circumferential ASM fibres embedded in parenchymal tissue and model the active contractile force generated by ASM via a stress acting along the fibres. A constitutive law is proposed that accounts for active and passive material properties as well as the proportion of muscle to connective tissue. The model predicts significantly different contractile responses depending on the proportion of muscle to connective tissue in the remodelled airway. We find that radial and hoop-stress distributions in remodelled muscle layers are highly heterogenous with distinct regions of compression and tension. Such patterns of stress are likely to have important implications, from a mechano-transduction perspective, on contractility, short-term cytoskeletal adaptation and long-term airway remodelling in asthma.

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Citations

May 4, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mohammad Afzal KhanLuke J Janssen
Apr 14, 2012·Journal of Applied Physiology·Baoshun Ma, Jason H T Bates
Nov 7, 2012·Respiratory Physiology & Neurobiology·Baoshun MaJason H T Bates
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Mar 31, 2015·Respiratory Physiology & Neurobiology·Baoshun MaJason H T Bates
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Jun 28, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Graham M Donovan
Jul 5, 2016·Journal of Theoretical Biology·Graham M Donovan
Aug 26, 2016·Frontiers in Physiology·Jonathan E HiornsBindi S Brook
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Jul 4, 2018·Biomechanics and Modeling in Mechanobiology·Michael R HillBindi S Brook
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May 17, 2012·American Journal of Respiratory and Critical Care Medicine·Alastair Stewart
Jan 22, 2011·Journal of Applied Physiology·D E Moulton, A Goriely
Feb 1, 2014·Journal of Applied Physiology·Baoshun Ma, Jason H T Bates
Mar 16, 2021·Journal of Mathematical Biology·Hannah J PybusBindi S Brook
Aug 15, 2021·Scientific Reports·Jungwook PaekDan Dongeun Huh

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