A biomimetic hybrid material consisting of CaCO3 mesoporous microspheres and an alternating copolymer for reversed-phase HPLC

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Mai MochidaYuki Hiruta

Abstract

We developed a biomineral-inspired hybrid material composed of CaCO3 and an organic polymer as a column packing material for HPLC. This material combines a hierarchical mesoporous structure and the functionality of the polymer. The surface of monodispersed mesoporous CaCO3 microspheres was modified with poly(maleic acid-alt-1-octadecene) (PMAcO) comprising hydrophobic alkyl chains and anionic carboxylate groups. PMAcO adsorbed onto the surface of CaCO3 through electrostatic interaction between Ca2+ sites and carboxylate groups, resulting in an octadecene coated microsphere interface. These microspheres were applied as a HPLC column and exhibited reversed-phase retention behavior in the separation of alkylbenzenes. This column showed high alkaline mobile phase resistance compared with the conventionally applied ODS column packing material. Quantitative analysis of the basic antidepressants clomipramine and imipramine spiked into whole blood was achieved with an alkaline mobile phase, demonstrating the potential of the biomineral-inspired material as a HPLC stationary phase for practical applications in routine analyses of basic drugs requiring alkaline mobile phases.

References

Jan 1, 1970·Respiration Physiology·O D WangensteenH Rahn
Aug 28, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Sungjin Kim, Chan Beum Park
Feb 14, 2015·Chemistry : a European Journal·Kosuke SatoHiroaki Imai
May 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Atsuharu InoueHiroaki Imai

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scanning electron microscopy
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