A biomimetic nanoenzyme for starvation therapy enhanced photothermal and chemodynamic tumor therapy.

Nanoscale
Keqiang XuHaiyuan Zhang

Abstract

Photothermal therapy (PTT) and chemodynamic therapy (CDT) are promising therapeutic modalities with high specificity, however, a single therapeutic modality cannot maximize therapeutic efficacy. In the present study, glucose oxidase (GOx) was decorated on N-doped carbon (NC) nanoparticles (NPs) as a biomimetic nanoenzyme (NC@GOx NPs), which could promote starvation therapy enhanced PTT and CDT against tumors. GOx could decompose to cut off the supply of energy and nutrients, inducing starvation therapy, which further lowered adenosine triphosphate (ATP) levels, inducing downregulated heat shock proteins and creating a more suitable microenvironment for improving PTT efficacy. Meanwhile, the generated endogenous hydrogen peroxide (H2O2) could be converted into hydroxyl radicals to attack cancer cells. In fact, in vitro and in vivo experiments demonstrated that NC@GOx NPs could effectively kill cancer cells and eliminate tumors. This design provides a strategy for synergistic cancer therapy by using biomimetic nanoenzymes.

References

Apr 9, 2013·Carcinogenesis·Maureen E Murphy
Jan 20, 2015·Journal of the American Chemical Society·Liming WangChunying Chen
Apr 19, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Nathalie van den TempelRoland Kanaar
Aug 27, 2017·Nature Communications·Minfeng HuoJianlin Shi
Jan 18, 2018·ACS Applied Materials & Interfaces·Lei FanRong Guo
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Apr 14, 2018·Nature Communications·Kelong FanLizeng Gao
Jun 15, 2019·Journal of the American Chemical Society·Li-Sen LinXiaoyuan Chen

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Methods Mentioned

BETA
protein assay
fluorescence imaging
xenograft
X-ray
Florescence

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