A 'bioproduction breadboard': programming, assembling, and actuating cellular networks

Current Opinion in Biotechnology
Amin ZargarWilliam E Bentley

Abstract

With advances in synthetic biology and biofabrication, cellular networks can be functionalized and connected with unprecedented sophistication. We describe a platform for the creation of a 'bioproduction breadboard'. This would consist of physically isolated product-producing cell populations, product capture devices, and other unit operations that function as programmed in place, using unique, orthogonal inputs. For product synthesis, customized cell populations would be connected through standardized, generic inputs allowing 'plug and play' functionality and primary, user-mediated regulation. In addition, through autonomous pathway redirection and balancing, the cells themselves would provide secondary, self-directed regulation to optimize bioproduction. By leveraging specialization and division of labor, we envision diverse cell populations linked to create new pathway designs.

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Citations

Oct 30, 2016·Metabolic Engineering·Narendranath BhokishamWilliam E Bentley
Mar 15, 2020·Annual Review of Chemical and Biomolecular Engineering·Sally WangWilliam E Bentley
Apr 24, 2019·Nature Biomedical Engineering·Ferdinand SedlmayerMartin Fussenegger
Sep 28, 2017·Chem·Jessica L ClearyLaura M Sanchez

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