A biosensor that uses ion-channel switches

Nature
B A CornellR J Pace

Abstract

Biosensors are molecular sensors that combine a biological recognition mechanism with a physical transduction technique. They provide a new class of inexpensive, portable instrument that permit sophisticated analytical measurements to be undertaken rapidly at decentralized locations. However, the adoption of biosensors for practical applications other than the measurement of blood glucose is currently limited by the expense, insensitivity and inflexibility of the available transduction methods. Here we describe the development of a biosensing technique in which the conductance of a population of molecular ion channels is switched by the recognition event. The approach mimics biological sensory functions and can be used with most types of receptor, including antibodies and nucleotides. The technique is very flexible and even in its simplest form it is sensitive to picomolar concentrations of proteins. The sensor is essentially an impedance element whose dimensions can readily be reduced to become an integral component of a microelectronic circuit. It may be used in a wide range of applications and in complex media, including blood. These uses might include cell typing, the detection of large proteins, viruses, antibodies, DNA, e...Continue Reading

References

Jun 12, 1986·Biochimica Et Biophysica Acta·H M McConnellA A Brian
Nov 1, 1995·Biophysical Journal·S B HladkyW J Fitzgerald
Dec 1, 1995·Protein Science : a Publication of the Protein Society·S HeyseH Sigrist
Jan 1, 1996·Biosensors & Bioelectronics·S R ReikenH Sutisna
Jan 1, 1996·Annual Review of Biophysics and Biomolecular Structure·R E Koeppe, O S Anderson
Feb 1, 1993·Biophysical Journal·E L Florin, H E Gaub

❮ Previous
Next ❯

Citations

Aug 6, 1998·Biopolymers·G TuchschererM Mutter
Nov 11, 1999·Journal of Molecular Recognition : JMR·G WoodhouseB Cornell
Dec 26, 2001·Biotechnology and Bioengineering·Wilfrid BoireauDenis Pompon
Apr 7, 2006·Analytical and Bioanalytical Chemistry·Andreas Janshoff, Claudia Steinem
Apr 17, 2008·Analytical and Bioanalytical Chemistry·F Lisdat, D Schäfer
Jul 29, 2009·Analytical and Bioanalytical Chemistry·Claus Hélix Nielsen
Apr 24, 2010·Analytical and Bioanalytical Chemistry·Marco FrasconiTommaso Ferri
Nov 15, 2011·Analytical and Bioanalytical Chemistry·L StellerR Salzer
Jul 6, 2007·European Biophysics Journal : EBJ·Claire Rossi, Joël Chopineau
Sep 13, 2011·Bioprocess and Biosystems Engineering·Sung-Ho JungTae-Joon Jeon
Feb 9, 2008·Biomedical Microdevices·Parijat BhatnagarJun Kameoka
Apr 20, 2004·Biosensors & Bioelectronics·O WorsfoldT Nishiya
Oct 26, 2005·Biosensors & Bioelectronics·Toshiya Sakata, Yuji Miyahara
Mar 17, 2004·Bioorganic & Medicinal Chemistry·Shiroh FutakiYukio Sugiura
Mar 17, 2004·Bioorganic & Medicinal Chemistry·Eric BironNormand Voyer
Jun 1, 2005·Trends in Parasitology·Paul T MonisR C Andrew Thompson
Dec 26, 2001·Biochimica Et Biophysica Acta·Vitali BorisenkoG Andrew Woolley
Nov 24, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·P B LuppaD W Chan
Mar 6, 2003·Journal of Colloid and Interface Science·T BaumgartW Knoll
Sep 6, 2003·Journal of Immunological Methods·Jay T Groves, Michael L Dustin
Feb 27, 2001·Toxicon : Official Journal of the International Society on Toxinology·P VélezB A Suárez-Isla
May 20, 1998·Trends in Biotechnology·H W Hellinga, J S Marvin
Jun 19, 2002·Bio Systems·Katarzyna Bogunia-Kubik, Masanori Sugisaka
Nov 7, 1998·Biochimica Et Biophysica Acta·S HeyseH Vogel
Jan 6, 2001·Journal of Biotechnology·W KnollA Sinner
Feb 7, 2003·Trends in Biotechnology·Giuliano EliaDario Neri
Feb 10, 2007·Analytical Chemistry·Ji Wook Shim, Li Qun Gu
May 18, 2013·Accounts of Chemical Research·Shiroh FutakiKoji Asami
Aug 13, 2013·Accounts of Chemical Research·Michael Mayer, Jerry Yang
Nov 17, 2012·Chemical Reviews·Joseph W F RobertsonSoojay Banerjee
Jan 9, 2008·Journal of the American Chemical Society·Michael MayerGeorge M Whitesides
Sep 9, 2011·Journal of the American Chemical Society·Nicolas FollietThierry Azaïs
Jan 29, 2009·Journal of the American Chemical Society·Juewen LiuC Jeffrey Brinker
May 1, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Wilma Febo-AyalaDavid H Thompson
May 25, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Kazuaki Furukawa, Takashi Aiba
Jun 28, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaoyin XiaoSusan M Brozik
Jun 29, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Thamara LaredoJacek Lipkowski
Aug 27, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Matthew K Strulson, Joshua A Maurer
Nov 30, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Lina ZhongM Lane Gilchrist

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