A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat.

PloS One
Maïte HotteGuenaëlle Levallet

Abstract

We aimed to further understand the relationship between cAMP concentration and mnesic performance. Rats were injected with milrinone (PDE3 inhibitor, 0.3 mg/kg, i.p.), rolipram (PDE4 inhibitor, 0.3 mg/kg, i.p.) and/or the selective 5-HT4R agonist RS 67333 (1 mg/kg, i.p.) before testing in the object recognition paradigm. Cyclic AMP concentrations were measured in brain structures linked to episodic-like memory (i.e. hippocampus, prefrontal and perirhinal cortices) before or after either the sample or the testing phase. Except in the hippocampus of rolipram treated-rats, all treatment increased cAMP levels in each brain sub-region studied before the sample phase. After the sample phase, cAMP levels were significantly increased in hippocampus (1.8 fold), prefrontal (1.3 fold) and perirhinal (1.3 fold) cortices from controls rat while decreased in prefrontal cortex (∼0.83 to 0.62 fold) from drug-treated rats (except for milrinone+RS 67333 treatment). After the testing phase, cAMP concentrations were still increased in both the hippocampus (2.76 fold) and the perirhinal cortex (2.1 fold) from controls animals. Minor increase were reported in hippocampus and perirhinal cortex from both rolipram (respectively, 1.44 fold and 1.70 fold...Continue Reading

References

Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
May 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·W Krause, G Kühne
May 1, 1986·Journal of Medicinal Chemistry·D W RobertsonJ S Hayes
Jan 19, 1971·Biochemistry·W J Thompson, M M Appleman
Oct 1, 1982·Pharmacology, Biochemistry, and Behavior·C T RandtD Quartermain
Feb 1, 1995·Drug and Chemical Toxicology·S Desjardins, M J Cauchy
Dec 31, 1996·Brain Research. Molecular Brain Research·M T VilaróG Mengod
Apr 1, 1997·Neuropharmacology·S LettyG Rondouin
Aug 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R BernabeuJ H Medina
Sep 4, 1998·Frontiers in Bioscience : a Journal and Virtual Library·C J Oliver, S Shenolikar
Oct 24, 1998·The European Journal of Neuroscience·A Parker, D Gaffan
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M BaradE Kandel
May 26, 1999·Pharmacology, Biochemistry, and Behavior·J M O'Donnell, S Frith
Oct 8, 1999·Journal of Psychopharmacology·J S SilvestreJ M Palacios
Jul 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H T ZhangJ M O'Donnell
Jul 27, 2001·Current Opinion in Chemical Biology·Z HuangA Robichaud
Sep 7, 2001·Neuropharmacology·V LelongM Boulouard
Sep 12, 2001·Progress in Nucleic Acid Research and Molecular Biology·M D Houslay

❮ Previous
Next ❯

Citations

May 27, 2014·Journal of Chemical Information and Modeling·Alban LepailleurSylvain Rault
Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cédric LecouteyPatrick Dallemagne
Jul 26, 2013·Expert Opinion on Therapeutic Targets·Wito RichterMarco Conti
Jun 7, 2014·Frontiers in Neuroscience·Yuri A BlednovR Adron Harris
Jun 28, 2014·Frontiers in Behavioral Neuroscience·Alfredo Meneses
Jun 16, 2016·Frontiers in Neuroscience·Mohammad A KhanfarHolger Stark
Jul 31, 2014·Psychopharmacology·A MenesesM Leopoldo

❮ Previous
Next ❯

Software Mentioned

SPSS
TotalLab Image Analysis
Sigma Stat

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.