A bistable switch in dynamic thiodepsipeptide folding and template-directed ligation

Angewandte Chemie
Rakesh MukherjeeGonen Ashkenasy

Abstract

Bistable reaction networks provide living cells with chemically controlled mechanisms for long-term memory storage. Such networks are also often switchable and can be flipped from one state to the other. We target here a major challenge in systems chemistry research, namely developing synthetic, non-enzymatic, networks that mimic such a complex function. Therefore, we describe a dynamic network that depending on initial thiodepsipeptide concentrations leads to one of two distinct steady states. This bistable system is readily switched by applying the appropriate stimuli. The relationship between the reaction network topology and its capacity to invoke bistability is then analyzed by control experiments and theory. We suggest that demonstrating bistable behavior using synthetic networks further highlights their possible role in early evolution, and may shine light on potential utility for novel applications, such as chemical memories.

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Citations

Apr 19, 2017·Chemical Society Reviews·Gonen AshkenasyAnnette F Taylor
Jan 24, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Nathaniel WagnerGonen Ashkenasy
Nov 13, 2015·Chemical Communications : Chem Comm·Ignacio Alfonso
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Aug 1, 2019·Life·Tamás Bánsági, Annette F Taylor
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Oct 13, 2019·Nature Communications·Indrajit MaityGonen Ashkenasy
Sep 26, 2020·Chemical Communications : Chem Comm·Jordi SolàIgnacio Alfonso
Feb 27, 2020·Chemical Reviews·Moran Frenkel-PinterLuke J Leman
May 22, 2021·Nature Communications·Alexander I NovichkovSergey N Semenov
Jun 23, 2021·Physical Chemistry Chemical Physics : PCCP·David Hochberg, Josep M Ribó
Sep 15, 2017·Journal of the American Chemical Society·Yigit AltaySijbren Otto

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