A blinded comparison of three laboratory protocols for the identification of patients colonized with methicillin-resistant Staphylococcus aureus

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
M GardamJ Conly

Abstract

To compare three laboratory screening protocols for the detection of methicillin-resistant Staphylococcus aureus (MRSA) from surveillance specimens (mannitol-salt agar containing 2 microg/mL of oxacillin [MSA-2], mannitol-salt agar containing 4 microg/mL of oxacillin [MSA-4], and a broth-containing protocol as recommended by the American Society for Microbiology [M-ASM]). Blinded comparative laboratory study and cost analysis. University-affiliated microbiology laboratory. Outcome measurements included rate of detection of MRSA-positive specimens and patients, turnaround time, and media and technologist costs. All MRSA culture swabs obtained from any patient site from November 1998 to April 1999 were included. The M-ASM protocol detected between 19.1% and 32.0% more MRSA-positive specimens and between 13.3% and 23.3% more MRSA-positive patients per surveillance event than the MSA-4 and MSA-2 protocols, respectively. There was no difference in positive-culture reporting time between the M-ASM and MSA4 protocols. The broth-containing protocol was 2- to 2.5-fold more expensive than the simpler protocols, taking into account media and laboratory personnel costs. It remains to be determined whether it is cost beneficial for a hospit...Continue Reading

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Citations

Mar 2, 2011·American Journal of Infection Control·Kathleen A RyanLindsay A Thompson
Aug 19, 2007·The Journal of Hospital Infection·Jan Kluytmans
Nov 24, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I NahimanaD S Blanc
Jul 11, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Benedict Lim Heng SimCaroline Marshall
Jul 16, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Christine MooreAllison McGeer
Aug 12, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Janet RaboudAllison McGeer
Nov 19, 2005·The Journal of Antimicrobial Chemotherapy·Derek F J BrownUNKNOWN Infection Control Nurses Association
Oct 13, 2005·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·W D SplettstoesserP Schuff-Werner

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