A blinded, crossover study of the efficacy of the ketogenic diet

Epilepsia
J M FreemanSteven N Goodman

Abstract

Despite over 80 years of use, the ketogenic diet (KD) has never been tested in a blinded manner. Twenty children with intractable Lennox-Gastaut syndrome (LGS) were fasted 36 h and then randomized to receive the classic KD in conjunction with a solution containing either 60 g/day of glucose or saccharin. Parents and physicians were blinded to both the solution composition and level of ketosis. A crossover to the KD with the alternate solution occurred following the sixth day and a repeat fast. A 24-h electroencephalography (EEG) was obtained at baseline and after each arm. After administration of the solution, there was moderate evidence of a reduction in parent-reported seizures between the glucose and saccharin arms, with a median difference of 1.5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm.

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Citations

Nov 7, 2009·Current Treatment Options in Neurology·Sumit ParikhThe Mitochondrial Medicine Society
Mar 9, 2013·Current Treatment Options in Neurology·Monica E Lemmon, Eric H Kossoff
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eric H Kossoff, Jong M Rho
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Feb 14, 2009·Epilepsia·Shlomo Shinnar
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Feb 14, 2009·Epilepsia·J Helen Cross
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