A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

Scientific Reports
Steve PedriniAIBL Research Group

Abstract

Alzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ε4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ε4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD a...Continue Reading

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Citations

Jun 16, 2018·Biomarkers in Medicine·Nicholas J AshtonHenrik Zetterberg
Jan 8, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Donald R RoyallUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 27, 2020·Immunological Reviews·Hannah E Ennerfelt, John R Lukens
Sep 13, 2020·Journal of Neurochemistry·Carmen Peña-BautistaConsuelo Cháfer-Pericás
Nov 7, 2019·Acta Neuropathologica Communications·Christopher D WhelanOskar Hansson
Feb 15, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miriam T AshfordMichael W Weiner
Apr 27, 2021·Frontiers in Neurology·Louisa NitschMarcus Müller
Jan 11, 2022·CNS Drugs·Laiba AzharNathan Herrmann

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Methods Mentioned

BETA
blood drawn
genotyping
blood

Software Mentioned

TIBCO Spotfire S +

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