Sep 19, 2017

A blood-based signature of cerebral spinal fluid Aβ1-42 status

BioRxiv : the Preprint Server for Biology
Benjamin GoudeyN G Faux

Abstract

It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of interventions aimed at slowing down rates of cognitive decline. Recent evidence indicates that of the two established methods for measuring amyloid, a decrease in cerebral spinal fluid (CSF) amyloid β (Aβ1-42) may be an earlier indicator of Alzheimer's disease risk than measures of amyloid obtained from Positron Emission Topography (PET). However, CSF collection is highly invasive and expensive. In contrast, blood collection is routinely performed, minimally invasive and cheap. In this work, we develop a blood-based signature that can provide a cheap and minimally invasive estimation of an individual's CSF amyloid status. We show that a Random Forest model derived from plasma analytes can accurately predict subjects as having abnormal (low) CSF Aβ1-42 levels indicative of AD risk (0.84 AUC, 0.73 sensitivity, and 0.76 specificity). Post-hoc analysis indicates that only six analytes are required to achieve similar performance. Furthermore, we show across an independent validati...Continue Reading

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Mentioned in this Paper

Biological Markers
Study
APP protein, human
Collection of Blood Specimen for Laboratory Procedure
Positron-Emission Tomography
Granulocyte Colony-Stimulating Factor
Serum Proteins
Plasma Protein Assay
Cerebrospinal Fluid
Alzheimer's Disease

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