A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development

Development
Cathy Pichol-ThievendMathias Francois

Abstract

Despite the essential role of the lymphatic vasculature in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial progenitor cells remains limited. The assumption that most murine embryonic lymphatic endothelial cells (LECs) are venous derived has recently been challenged. Here, we show that the embryonic dermal blood capillary plexus constitutes an additional, local source of LECs that contributes to the formation of the dermal lymphatic vascular network. We describe a novel mechanism whereby rare PROX1-positive endothelial cells exit the capillary plexus in a Ccbe1-dependent manner to establish discrete LEC clusters. As development proceeds, these clusters expand and further contribute to the growing lymphatic system. Lineage tracing and analyses of Gata2-deficient mice confirmed that these clusters are endothelial in origin. Furthermore, ectopic expression of Vegfc in the vasculature increased the number of PROX1-positive progenitors within the capillary bed. Our work reveals a novel source of lymphatic endothelial progenitors employed during construction of the dermal lymphatic vasculature and demonstrates that the blood vasculature is likely to remain an ongoing source of LECs duri...Continue Reading

References

Jan 14, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M SchneiderJ Wilting
Nov 7, 2000·Genesis : the Journal of Genetics and Development·T MotoikeT N Sato
Feb 13, 2001·Developmental Biology·Y Y KisanukiM Yanagisawa
Apr 12, 2001·BMC Developmental Biology·S SrinivasF Costantini
Aug 24, 2005·Nature Medicine·Annelii NyPeter Carmeliet
Feb 7, 2006·Developmental Biology·Jörg WiltingMaria Papoutsi
Oct 3, 2007·Genes & Development·R Sathish SrinivasanGuillermo Oliver
Feb 22, 2008·Journal of the American Society of Nephrology : JASN·Andrew P McMahonUNKNOWN GUDMAP project
Feb 29, 2008·Developmental Biology·Masanori HirashimaToshio Suda
Oct 22, 2008·Nature·Mathias FrançoisPeter Koopman
Mar 17, 2009·Nature Genetics·Benjamin M HoganStefan Schulte-Merker
Dec 23, 2009·The Journal of Experimental Medicine·Trung H M PhamJason G Cyster
Jun 19, 2010·Blood·Jan KazenwadelNatasha L Harvey
Jul 24, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maarja HaugasMarjo Salminen
Nov 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Cara C BertozziMark L Kahn
Nov 22, 2012·Nature Communications·Caleb S HeffnerStephen A Murray
May 8, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Wenling Li, Yoh-suke Mukouyama
Dec 4, 2013·The Journal of Experimental Medicine·Xin GaoEmery H Bresnick
Dec 4, 2013·The Journal of Experimental Medicine·Emma de PaterElaine Dzierzak
Mar 5, 2015·Circulation Research·Ines Martinez-CorralTaija Makinen
Jul 28, 2015·The Journal of Clinical Investigation·Jan KazenwadelNatasha L Harvey
Apr 10, 2016·Genesis : the Journal of Genetics and Development·Maria H UlvmarTaija Mäkinen
Nov 17, 2017·The Journal of Experimental Medicine·Salli AntilaKari Alitalo

❮ Previous
Next ❯

Citations

Mar 20, 2020·Development·Marco MonroyMichael T Dellinger
Sep 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefania MartuccielloElizabeth Illingworth
Feb 12, 2020·Cold Spring Harbor Perspectives in Biology·Rudra Nayan Das, Karina Yaniv
Aug 15, 2020·Frontiers in Physiology·Kazuhide S Okuda, Benjamin M Hogan
May 2, 2020·Molecular Psychiatry·Alexios-Fotios A MentisGeorge P Chrousos
May 20, 2020·The Journal of Clinical Investigation·Zoe L GrantLeigh Coultas
Oct 20, 2020·Frontiers in Physiology·Laura Gutierrez-Miranda, Karina Yaniv
Jan 20, 2021·Nature Reviews. Cardiology·Konstantinos KlaourakisPaul R Riley
Dec 15, 2020·Advanced Drug Delivery Reviews·Alejandra González-Loyola, Tatiana V Petrova
Apr 29, 2018·Current Opinion in Immunology·Jan Kazenwadel, Natasha L Harvey
Apr 8, 2021·Angiogenesis·Daniyal J JafreeChristiana Ruhrberg
Apr 13, 2021·Angiogenesis·Corina MarzianoKaren K Hirschi
May 18, 2021·Frontiers in Pharmacology·Sofia Pereira das NevesSandro Da Mesquita
Jun 20, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Oliver A StoneDidier Y R Stainier
Jun 25, 2021·Circulation Research·Taija MäkinenKari Alitalo
Jul 10, 2021·Cellular and Molecular Life Sciences : CMLS·Xin GengR Sathish Srinivasan
Jul 25, 2021·International Journal of Molecular Sciences·Genevieve A Secker, Natasha L Harvey
Oct 30, 2021·Lymphatic Research and Biology·Xiaoteng FengPing Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.