A blood pressure independent index of aortic distensibility

The British Journal of Radiology
E D LehmannM G Taylor

Abstract

A non-invasive Doppler ultrasound technique for the assessment of aortic compliance based on the in vivo measurement of pulse wave velocity along the thoraco-abdominal aortic pathway is described. An approach for correcting for the effect of blood pressure on aortic compliance is considered. The derivation of an index of distensibility, Cp, which is independent of blood pressure is provided and applied to data collected from 58 normal, healthy volunteers. Medical disorders such as atherosclerosis, diabetes mellitus and familial hypercholesterolaemia have all been shown to affect arterial distensibility. We suggest that the clinical measurement of Cp may be a useful, non-invasive tool for assessing such patients' susceptibility to atheromatous arterial disease as well as for monitoring their response to therapy.

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Citations

Mar 1, 1996·Cardiovascular Drugs and Therapy·K Breithaupt-GröglerW Sinn
Jul 1, 1994·The British Journal of Radiology·E D LehmannR G Gosling
Feb 1, 1995·Cardiovascular Drugs and Therapy·G G Belz
May 28, 2010·Journal of Human Hypertension·R CampbellM P Frenneaux
Nov 7, 1992·Lancet·E D LehmannR G Gosling
Jan 1, 1993·Ultrasound in Medicine & Biology·E D LehmannR G Gosling
Apr 1, 2004·The Korean Journal of Internal Medicine·Moo-Yong RheeYoung-Kwon Kim
May 21, 2003·Hypertension·Raymond G Gosling, Marc M Budge
Sep 3, 2003·Periodontology 2000·Gösta Granström

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