A Brain-Heart Biomarker for Epileptogenesis

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Fatemeh BahariBruce J Gluckman

Abstract

Postinjury epilepsy is an potentially preventable sequela in as many as 20% of patients with brain insults. For these cases biomarkers of epileptogenesis are critical to facilitate identification of patients at high-risk of developing epilepsy and to introduce effective anti-epileptogenic interventions. Here, we demonstrate that delayed brain-heart coincidences serve as a reliable biomarker. In a murine model of post-infection acquired epilepsy, we used long-term simultaneous measurements of the brain activity via electroencephalography and autonomic cardiac activity via electrocardiography, in male mice, to quantitatively track brain-heart interactions during epileptogenesis. We find that abnormal cortical discharges precede abnormal fluctuations in the cardiac rhythm at the resolution of single beat-to-beat intervals. The delayed brain-heart coincidence is detectable as early as the onset of chronic measurements, 2-14 weeks before the first seizure, only in animals that become epileptic, and increases during epileptogenesis. Therefore, delayed brain-heart coincidence serves as a biomarker of epileptogenesis and could be used for phenotyping, diagnostic, and therapeutic purposes.SIGNIFICANCE STATEMENT No biomarker that readily...Continue Reading

Citations

Sep 19, 2019·Epilepsy Currents·Rui Li, Gordon F Buchanan
Jul 17, 2020·Brain Communications·Dakota N CrispWilliam C Stacey
Feb 18, 2021·Nature Reviews. Neurology·Michele SimonatoKaren S Wilcox

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