A Brief Critique of the TATES Procedure

Behavior Genetics
Fazil AlievDanielle M Dick

Abstract

The Trait-based test that uses the Extended Simes procedure (TATES) was developed as a method for conducting multivariate GWAS for correlated phenotypes whose underlying genetic architecture is complex. In this paper, we provide a brief methodological critique of the TATES method using simulated examples and a mathematical proof. Our simulated examples using correlated phenotypes show that the Type I error rate is higher than expected, and that more TATES p values fall outside of the confidence interval relative to expectation. Thus the method may result in systematic inflation when used with correlated phenotypes. In a mathematical proof we further demonstrate that the distribution of TATES p values deviates from expectation in a manner indicative of inflation. Our findings indicate the need for caution when using TATES for multivariate GWAS of correlated phenotypes.

References

Mar 15, 2011·American Journal of Human Genetics·Miao-Xin LiPak C Sham
Jan 30, 2013·PLoS Genetics·Sophie van der SluisConor V Dolan
Apr 26, 2014·PloS One·Tessel E GaleslootSita H Vermeulen

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Citations

May 8, 2020·Environmental Science and Pollution Research International·Jinkai ZhaoKai Zhao

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