PMID: 9557695Apr 29, 1998Paper

A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4

Journal of Virology
A McKnightPaul R Clapham

Abstract

Like human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), HIV-2 requires a coreceptor in addition to CD4 for entry into cells. HIV and SIV coreceptor molecules belong to a family of seven-transmembrane-domain G-protein-coupled receptors. Here we show that primary HIV-2 isolates can use a broad range of coreceptor molecules, including CCR1, CCR2b, CCR3, CCR4, CCR5, and CXCR4. Despite broad coreceptor use, the chemokine ligand SDF-1 substantially blocked HIV-2 infectivity of peripheral blood mononuclear cells, indicating that its receptor, CXCR4, was the predominant coreceptor for infection of these cells. However, expression of CXCR4 together with CD4 on some cell types did not confer susceptibility to infection by all CXCR4-using virus isolates. These data therefore indicate that another factor(s) influences the ability of HIV-2 to replicate in human cell types that express the appropriate receptors for virus entry.

Citations

May 20, 1999·Molecular Membrane Biology·P R ClaphamA McKnight
Jan 31, 2002·AIDS·P J Bock, D M Markovitz
Sep 24, 2009·Journal of Medical Virology·Quirina Santos-CostaJosé Miguel Azevedo-Pereira
Sep 10, 2011·AIDS Research and Human Retroviruses·Maria Espirito-SantoJ Miguel Azevedo-Pereira
Jun 5, 1999·AIDS Research and Human Retroviruses·M T DittmarL Gürtler
Jul 19, 2002·The Journal of General Virology·Paul R Clapham, Aine McKnight
Apr 9, 2008·Expert Review of Vaccines·Aleksandra Leligdowicz, Sarah Rowland-Jones
Mar 27, 2009·AIDS Research and Human Retroviruses·Rita CavaleiroAna E Sousa
Sep 15, 2004·Acta Microbiologica Et Immunologica Hungarica·Dalma Vödrös, Eva Mária Fenyö
Dec 6, 2011·The Journal of Infectious Diseases·Benoit VisseauxUNKNOWN ANRS CO 05 HIV-2 Cohort
May 25, 2002·The Journal of General Virology·Jacqueline D Reeves, Robert W Doms
Feb 15, 2001·AIDS Research and Human Retroviruses·Y J ZhangJ P Moore
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·E G KokkotouP J Kanki
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Lokesh AgrawalLokesh Agrawal
Jul 20, 2001·AIDS Research and Human Retroviruses·B J MarguliesJ E Clements

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