PMID: 9552710Jan 1, 1997Paper

A broad-spectrum antifungal from the marine sponge Hyrtios erecta

International Journal of Antimicrobial Agents
R K PettitZbigniew A Cichacz

Abstract

Spongistatin 1, a macrocyclic lactone polyether from the marine sponge Hyrtios erecta, was fungicidal for a variety of opportunistic yeasts and filamentous fungi, including strains resistant to amphotericin B, ketoconazole and flucytosine. In broth macrodilution assays, MICs ranged from 0.195 to 12.5 microg/ml, and minimum fungicidal concentrations ranged from 3.12 to 25 microg/ml. Initial disk diffusion screens with six related macrocyclic lactone polyethers from H. erecta and Spirastrella spinispirulifera, revealed that these polyethers were also antifungal. The fungicidal activity of spongistatin 1 was confirmed in killing kinetics studies, where killing of Candida albicans and Cryptococcus neoformans occurred within 6 and 12 h, respectively. During the killing kinetics experiments, non-treated C. albicans maintained the yeast morphology. However, elongated forms resembling germ tubes were the predominant morphologic form in spongistatin 1-treated C. albicans cultures. The spongistatins show promise as potential antifungal agents and as probes to study fungal morphogenesis and nuclear division.

References

Oct 4, 1995·Journal of the National Cancer Institute·J McCann
Nov 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S E VartivarianG P Bodey
Oct 1, 1995·Clinical Microbiology Reviews·K C Hazen
Aug 1, 1996·Journal of Natural Products·G R Pettit
Apr 1, 1996·Emerging Infectious Diseases·N M Ampel

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Citations

May 1, 2002·Folia Microbiologica·B R MohapatraA Sree
Mar 19, 2005·Marine Biotechnology·Detmer SipkemaRené H Wijffels
Sep 24, 2005·Medical Mycology·Robin K PettitCherry L Herald
Feb 18, 2010·Tetrahedron·Amos B SmithRobert E Lee Trout
Jul 2, 2005·Expert Opinion on Emerging Drugs·Elisabeth J Ruijgrok, Jaques F G M Meis
Jul 23, 2009·Chemistry & Biodiversity·Pt Kartikay Pandey
Jun 14, 2002·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Frances Annie Pettit
Apr 26, 2019·Marine Drugs·Tomasz M Karpiński
Jun 25, 2005·Organic & Biomolecular Chemistry·Ian PatersonRoger D Norcross
Nov 20, 2020·Antibiotics·Chukwuemeka Samson AhamefuleWenxia Fang
Aug 3, 1999·Antimicrobial Agents and Chemotherapy·Y Y OvechkinaB R Oakley
Nov 6, 2007·Organic Letters·Sylvain FavrePierre Vogel
Jul 28, 2001·Journal of Natural Products·G R PettitM D Williams
Dec 15, 2005·Chemical Reviews·Kap-Sun Yeung, Ian Paterson

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