A bubble bursting-mediated oral drug delivery system that enables concurrent delivery of lipophilic and hydrophilic chemotherapeutics for treating pancreatic tumors in rats.

Biomaterials
Kuan-Hung ChenHsing-Wen Sung

Abstract

The therapeutic outcome of pancreatic cancer remains unsatisfactory, despite many attempts to improve it. To address this challenge, an oral drug delivery system that spontaneously initiates an effervescent reaction to form gas-bubble carriers is proposed. These carriers concurrently deliver lipophilic paclitaxel (PTX) and hydrophilic gemcitabine (GEM) in the small intestine. The bursting of the bubbles promotes the intestinal absorption of the drugs. The antitumor efficacy of this proposed oral drug delivery system is evaluated in rats with experimentally created orthotopic pancreatic tumors. The combined administration of equivalent amounts of PTX and GEM via the intravenous (i.v.) route, which is clinically used for treating pancreatic cancer, serves as a control. Following oral administration, the lipophilic PTX is initially absorbed through the intestinal lymphatic system and then enters systemic circulation, whereas the hydrophilic GEM is directly taken up into the blood circulation, ultimately accumulating in the tumorous pancreatic tissues. A pharmacokinetic study reveals that the orally delivered formulation has none of the toxic side-effects that are associated with the i.v. injected formulation; changes the pharmacok...Continue Reading

References

Oct 18, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C W Pouton
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Kenneth D SomersRichard P Ciavarra
May 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M C Bibby
Mar 6, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Birgit HotzHubert G Hotz
Mar 8, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lev Bromberg
May 21, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Chun-Nan YehMiin-Fu Chen
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabian ReuterAndreas Frey
Apr 20, 2013·International Journal of Pharmaceutics·René HolmHuiling Mu
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Suha Attili-QadriSimon Benita
Oct 18, 2013·The New England Journal of Medicine·Daniel D Von HoffMarkus F Renschler
Jan 5, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Søren H WellingStephen T Buckley
Oct 17, 2015·Nature Reviews. Drug Discovery·Natalie L TrevaskisChristopher J H Porter
Apr 16, 2016·Advanced Drug Delivery Reviews·Zhigao NiuMaría J Alonso
Apr 20, 2016·Advanced Drug Delivery Reviews·Orlagh M FeeneyChristopher J H Porter
Sep 7, 2016·Oncogene·E E MowersK F Macleod
Nov 17, 2017·Cancers·Manoj Amrutkar, Ivar P Gladhaug
Mar 20, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guanyu ChenJingyuan Wen
May 9, 2018·Cancer Science·Hiroyoshi Y Tanaka, Mitsunobu R Kano
Jul 24, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Ji-Hye KangUeon Sang Shin
Aug 8, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hailing YangRobert C Bast
Aug 22, 2018·Advanced Science·Po-Yen LinKam W Leong

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Citations

Jul 30, 2020·Journal of Colloid and Interface Science·Rui XiaZhigang Xie
Jul 17, 2021·Advanced Materials·Yang-Bao MiaoHsing-Wen Sung

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