PMID: 3159934Jun 1, 1985Paper

A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection

The Journal of Surgical Research
T S KupperD R Green

Abstract

Suppressor T cell activity after major burn injury in a murine model has been well characterized. Suppressor cells have also been demonstrated in patients after major burn, and suppressor cell activity has been temporally correlated with septic episodes. A splenic Ly-2 T suppressor effector (Tse) cell appearing 7 days after a 30% full thickness burn has been identified in a murine model. A rat monoclonal antibody (14-8c3-12) directed against a factor produced by the Tse cell (Tsef) can enhance depressed in vitro mixed lymphocyte reaction (MLR) responses of Day 7 burn spleen cells without enhancing control spleen cell activity. Additionally, 14-8c3-12 can block the suppressive effect of these burn T cells on normal T cells. A cecal ligation and puncture (CLP) model using a 25-gauge needle (LD15) was used to assess the contribution of burn T cells to post-CLP mortality. Normal spleen cells injected into syngeneic recipients followed by CLP did not affect mortality (13%). Burn spleen cells injected into normal recipients enhanced mortality sixfold (90%) after CLP. The effect could be reversed by removing Ly-2 T cells (30% mortality) but not Ly-1 T cells (100% mortality) prior to cell transfer. Simultaneous injection of 14-8c3-12 a...Continue Reading

References

Jun 1, 1977·The Journal of Surgical Research·C L Miller, D D Trunkey
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L J Wysocki, V L Sato
Feb 1, 1973·Annals of Surgery·A M MunsterR F Mortensen
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Citations

Oct 1, 1988·Journal of Reproductive Immunology·S L RibbingK D Beaman
Sep 1, 1988·Immunology Today·D R Green, E Faist
Jan 25, 2003·Burns : Journal of the International Society for Burn Injuries·Martin G Schwacha
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
Dec 1, 1994·The Australian and New Zealand Journal of Surgery·W J AdamsL Peters
Jun 1, 1988·The Journal of Surgical Research·M A GaddT O Field
Oct 1, 1993·The British Journal of Surgery·O CetinkaleA Pusane
May 20, 2003·Immunological Reviews·Thomas A FergusonThomas S Griffith
Nov 26, 2003·British Journal of Neurosurgery·D E BoddieS D Heys
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niamh Ni ChoileainJames A Lederer
Mar 1, 1990·DICP : the Annals of Pharmacotherapy·A Kumar
Mar 23, 2006·World Journal of Gastroenterology : WJG·Suna GuzelOzgur Mutlu
Jun 2, 1998·The British Journal of Surgery·M Schäffer, A Barbul
Oct 1, 1992·Clinical Immunology and Immunopathology·H SasakiF Suzuki

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