PMID: 3159934Jun 1, 1985Paper

A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection

The Journal of Surgical Research
T S KupperD R Green


Suppressor T cell activity after major burn injury in a murine model has been well characterized. Suppressor cells have also been demonstrated in patients after major burn, and suppressor cell activity has been temporally correlated with septic episodes. A splenic Ly-2 T suppressor effector (Tse) cell appearing 7 days after a 30% full thickness burn has been identified in a murine model. A rat monoclonal antibody (14-8c3-12) directed against a factor produced by the Tse cell (Tsef) can enhance depressed in vitro mixed lymphocyte reaction (MLR) responses of Day 7 burn spleen cells without enhancing control spleen cell activity. Additionally, 14-8c3-12 can block the suppressive effect of these burn T cells on normal T cells. A cecal ligation and puncture (CLP) model using a 25-gauge needle (LD15) was used to assess the contribution of burn T cells to post-CLP mortality. Normal spleen cells injected into syngeneic recipients followed by CLP did not affect mortality (13%). Burn spleen cells injected into normal recipients enhanced mortality sixfold (90%) after CLP. The effect could be reversed by removing Ly-2 T cells (30% mortality) but not Ly-1 T cells (100% mortality) prior to cell transfer. Simultaneous injection of 14-8c3-12 a...Continue Reading


Jun 1, 1977·The Journal of Surgical Research·C L Miller, D D Trunkey
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L J Wysocki, V L Sato
Feb 1, 1973·Annals of Surgery·A M MunsterR F Mortensen
Jan 1, 1971·International Archives of Allergy and Applied Immunology·K Eurenius, R F Mortensen
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G M IversonR K Gershon

❮ Previous
Next ❯


Oct 1, 1988·Journal of Reproductive Immunology·S L RibbingK D Beaman
Sep 1, 1988·Immunology Today·D R Green, E Faist
Jan 25, 2003·Burns : Journal of the International Society for Burn Injuries·Martin G Schwacha
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
Dec 1, 1994·The Australian and New Zealand Journal of Surgery·W J AdamsL Peters
Jun 1, 1988·The Journal of Surgical Research·M A GaddT O Field
Oct 1, 1993·The British Journal of Surgery·O CetinkaleA Pusane
May 20, 2003·Immunological Reviews·Thomas A FergusonThomas S Griffith
Nov 26, 2003·British Journal of Neurosurgery·D E BoddieS D Heys
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niamh Ni ChoileainJames A Lederer
Mar 1, 1990·DICP : the Annals of Pharmacotherapy·A Kumar
Mar 23, 2006·World Journal of Gastroenterology : WJG·Suna GuzelOzgur Mutlu
Jun 2, 1998·The British Journal of Surgery·M Schäffer, A Barbul
Oct 1, 1992·Clinical Immunology and Immunopathology·H SasakiF Suzuki

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.