PMID: 9655301Jul 9, 1998Paper

A c-rasHa mutation in the metastasis of a human papillomavirus (HPV)-18 positive penile squamous cell carcinoma suggests a cooperative effect between HPV-18 and c-rasHa activation in malignant progression

Cancer
P F LeisX J Wang

Abstract

Human papillomaviruses (HPV) have been implicated in the etiology of anogenital squamous epithelial tumors. Of the 65 HPV strains, subtypes HPV-16 and HPV-18 frequently are associated with malignant conditions and are capable of transforming keratinocytes in vitro. However, additional cellular changes are necessary to confer tumorigenicity to HPV-infected cells. Secondary events implicated in the progression to malignancy include loss of tumor suppressor genes such as p53 and/or activation of cellular oncogenes such as c-rasHa. Polymerase chain reaction (PCR) was used to identify HPV-16 or HPV-18 genetic sequence in primary penile squamous cell carcinoma and two inguinal lymph node metastases. p53 and c-rasHa loci were analyzed by sequencing of PCR-amplified genomic DNA. HPV-18 but not HPV-16 infection was found in the primary carcinoma and in inguinal metastases occurring 5 and 7 years after the initial lesion. Sequence analysis did not identify any p53 mutations in the primary carcinoma or its metastases. However, although the primary lesion and the 5-year metastasis encoded wild-type c-rasHa, the 7-year metastasis had a missense mutation within c-rasHa codon 61. To the authors' knowledge, this is the first report of an activ...Continue Reading

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Citations

Dec 10, 2009·Future Microbiology·Quoc V TuGeorge L Mendz
Aug 1, 2008·Expert Opinion on Medical Diagnostics·Ademar Lopes
Mar 22, 2008·The Journal of Urology·Patiyan AnderssonMats G Karlsson
May 1, 2007·The Lancet Oncology·Oliver KayesSuks Minhas
Jan 22, 2005·Critical Reviews in Oncology/hematology·Anna Maria MosconiChristine Theodore
Apr 23, 2015·PloS One·Manit AryaAamir Ahmed
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eve MaubecMarie-Françoise Avril
Jun 13, 2008·World Journal of Urology·Asif MuneerSuks Minhas
Jul 9, 2008·World Journal of Urology·M C G BleekerC J L M Meijer
Sep 2, 1999·British Journal of Cancer·P A Lazo

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