A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin

British Journal of Pharmacology
S R Hughes, S D Brain

Abstract

1. The effect of the calcitonin gene-related peptide (CGRP) antagonist CGRP8-37 on responses to CGRP and other mediators was investigated in rabbit dorsal skin. 2. Blood flow changes at intradermally-injected sites were measured by a multiple site 133xenon clearance technique. CGRP8-37 had little effect on blood flow at doses up to 0.3 nmol/site, when injected alone, although a significant increase in blood flow was observed at the highest dose tested (1 nmol/site). 3. CGRP8-37 dose-dependently inhibited the increased blood flow induced by human alpha CGRP and human beta CGRP, but had no effect on equivalent vasodilator responses induced by vasoactive intestinal peptide (VIP) and prostaglandin E1 (PGE1). CGRP8-37 showed a preferential ability to inhibit alpha CGRP (IC50 0.04 nmol), when compared with beta CGRP (IC50 greater than or equal to 0.3 nmol). 4. Capsaicin, which selectively activates sensory nerves, caused a dose-dependent increase in blood flow when injected intradermally into rabbit skin. The effects of capsaicin (0.01-0.1 mumol/site) were inhibited by CGRP8-37 (0.3 nmol/site), with a partial but significant attenuation of blood flow induced by the highest dose of capsaicin. 5. Oedema formation, induced by intraderma...Continue Reading

References

Mar 1, 1979·British Journal of Pharmacology·T J Williams
Sep 28, 1990·Biochemical and Biophysical Research Communications·S M GardinerB Hughes
Oct 1, 1986·The Journal of Investigative Dermatology·S D BrainT J Williams
Apr 22, 1985·FEBS Letters·P H SteenberghH S Jansz
May 27, 1986·European Journal of Pharmacology·S D BrainT J Williams
Jan 3, 1985·Nature·S D BrainI MacIntyre
Sep 21, 1984·Science·M G RosenfeldR M Evans

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Citations

Jan 1, 1994·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A FazekasD R Richardson
Sep 4, 1992·European Journal of Pharmacology·S R HughesS D Brain
Nov 24, 1995·European Journal of Pharmacology·A M ElhawaryC C Pang
Jan 1, 1992·Pharmacology & Therapeutics·D R Poyner
May 1, 1993·General Pharmacology·J Donnerer, R Amann
Apr 16, 1998·European Journal of Pharmacology·M Astin, J Stjernschantz
May 17, 2000·Burns : Journal of the International Society for Burn Injuries·L LindblomP Löwhagen Hendén
Oct 1, 1995·International Journal of Dermatology·S P RaychaudhuriE M Farber
Apr 20, 2005·Journal of Gastroenterology and Hepatology·Sumito MizuguchiMasataka Majima
Mar 1, 1993·British Journal of Pharmacology·P Newbold, S D Brain
Mar 1, 1994·British Journal of Pharmacology·M K Herbert, P Holzer
Aug 1, 1995·British Journal of Pharmacology·A M ElhawaryC C Pang
Feb 1, 1995·British Journal of Pharmacology·P Newbold, S D Brain
Mar 1, 1996·British Journal of Pharmacology·A E Tomlinson, D R Poyner
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·D F Rogers
Oct 11, 2005·Neuro-Signals·Louis Vera-Portocarrero, Karin N Westlund

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