PMID: 9169293May 1, 1997Paper

A calcium antagonistic effect of the new antiepileptic drug lamotrigine

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
J von WegererJ Walden

Abstract

The new antiepileptic drug lamotrigine (LTG; 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine) has been shown to be effective in the treatment of focal epilepsies with or without secondary generalization. Furthermore, some case reports indicate an efficacy in the treatment of bipolar affective disorders. It has been suggested that the main mechanism of action of LTG is the inhibition of glutamate release through blockade of voltage sensitive sodium channels and stabilisation of the neuronal membrane. Since some antidepressant drugs and the antiepileptic substance carbamazepine have calcium antagonistic properties, which may be of significance in the pathophysiology of epilepsies and affective disorders, the interaction of lamotrigine with carbamazepine and the organic calcium channel blocker verapamil was analyzed in the low Mg(2+)-induced model epilepsy which has been shown to be suppressed specifically by organic calcium antagonists. Lamotrigine reduced the frequency of occurrence of low-magnesium induced field potentials in CA1 and CA3 areas of the hippocampus slice preparation (guinea pigs) in a dose-dependent manner. The subthreshold concentrations which yielded no effect were 1 mumol/l for lamotrigine, 10 mumol/l for car...Continue Reading

References

Jan 1, 1992·Acta Neurologica Scandinavica. Supplementum·J WaldenE J Speckmann
Dec 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J WaldenR Düsing
Jan 1, 1991·Epilepsia·A W Peck
May 4, 1990·Neuroscience Letters·E G McGeer, S G Zhu
Jun 1, 1990·Clinical Neuropharmacology·G BrunetG Darcourt
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·J D LambertU Heinemann
Jan 1, 1995·Journal of Psychiatric Research·J WaldenH Grunze
Jan 1, 1994·Epilepsia·A W Yuen
Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·S L DubovskyJ Murphy
Dec 1, 1993·Psychiatry Research·P J PazzagliaL B Marangell
Jan 1, 1993·Neuropsychobiology·S L Dubovsky
Mar 1, 1996·Pflügers Archiv : European journal of physiology·N KlöckerE J Speckmann

❮ Previous
Next ❯

Citations

May 3, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·M KammererT J Feuerstein
Jul 8, 2005·Psychopharmacology·Charles H LargeDonald C Goff
Oct 26, 2000·Clinical Therapeutics·A A Ballasiotes, T L Skaer
Oct 6, 2001·Pediatric Neurology·A Di Martino, R F Tuchman
Feb 11, 2003·Epilepsy Research·Sharon C StrattonRussell M Hagan
Jul 16, 2005·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Christoph BornHeinz Grunze
Oct 2, 2003·Journal of Clinical Psychopharmacology·Terence A KetterRobert M Post
May 23, 2007·Pediatric Research·Emmanuelle LagruePierre Castelnau
Jul 1, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ignacio ValenciaAgustín Legido
Sep 6, 2005·Brain Research Bulletin·Valéria KecskemétiGéza Szûcs
Jan 27, 2015·Epilepsy Research·Michael A RogawskiChristian Wolff
Jun 11, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Martin AldaGlenda MacQueen
Sep 1, 2000·Acta Neuropsychiatrica·H C GrunzeJ Waiden
May 3, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I KidaK L Behar
Jan 1, 2008·International Journal of Psychiatry in Clinical Practice·Gurvinder Pal Singh
May 4, 2010·Journal of Mental Health·Heinz C R Grunze
Mar 19, 2020·Pharmacogenetics and Genomics·Taraswi Mitra-GhoshRuss B Altman
Sep 10, 2003·Drugs·David R GoldsmithCaroline M Perry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.