A calcium channel blocker flunarizine attenuates the neurotoxic effects of iron

Cell Biology and Toxicology
M Omer BostanciSinan Canan

Abstract

Iron is a metal highly concentrated in liver and brain tissue, and known to induce neuronal hyperactivity and oxidative stress. It has been established that iron levels rise in the brain in some neurodegenerative diseases such as Parkinson's and Alzheimer's diseases (AD). A body of evidence indicates a link between neuronal death and intracellular excessive calcium accumulation. The aim of the present study was to investigate the effects of a calcium antagonist, flunarizine, on neurotoxicity induced by intracerebroventricular (i.c.v.) iron injection. For this reason rats were divided into three groups as control, iron and iron+flunarizine groups. Animals in iron and iron+flunarizine groups received i.c.v. FeCl(3) injection (200 mM, 2.5 microl), while control rats received the same amount of saline into the cerebral ventricles. Rats in iron+flunarizine group also received i.c.v. flunarizine (1 microM, 2 microl) following FeCl(3) injection. All animals were kept alive for ten days following the operation and animals in iron+flunarizine group received intraperitoneal (i.p.) flunarizine injections once a day (10 mg/kg/day) during this period. After ten days, rats were sacrificed. The total numbers of neurons in hippocampus of all r...Continue Reading

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Citations

Oct 30, 2007·Cellular and Molecular Neurobiology·M Omer Bostanci, Faruk Bağirici
Oct 3, 2009·Cellular and Molecular Neurobiology·M Omer BostanciFaruk Bagirici
Jan 1, 2008·Toxicology Mechanisms and Methods·M Omer BostanciOrhan Bas
Apr 9, 2008·Brain Research Bulletin·M Omer Bostanci, Faruk Bağirici
Nov 21, 2007·Neurotoxicology·M Omer Bostanci, Faruk Bağirici
May 23, 2014·Frontiers in Physiology·Shanthini MylvaganamPeter L Carlen
Nov 14, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Nick CunniffeAlasdair Coles

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