A call for change in anticancer drug evaluation

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
E Cvitkovic

Abstract

In the evaluation of anticancer agents, the present emphasis on the use of measurements determining the drug's capacity for cytoxicity and tumour shrinking prevents oncologists from defining efficacy measures which may be more relevant to clinical reality. In addition, oncologists are not yet making adequate or appropriate use of the advanced technologies available, and the use of standardised response criteria does not ensure that results are clinically meaningful. There is a strong need for flexibility in the choice of the endpoint to be measured according to the type of cancer. It is important that faster, smaller-scale trial designs must be developed so that promising, new anticancer agents are made available as quickly as possible.

References

Dec 10, 1987·The New England Journal of Medicine·I F Tannock
Nov 29, 1965·JAMA : the Journal of the American Medical Association·J Gurland, R O Johnson
Jan 1, 1981·Cancer·A B MillerA Winkler

❮ Previous
Next ❯

Citations

May 2, 2001·Gynecologic Oncology·S M CamposM V Seiden
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Everardo D SaadMarc Buyse
Jul 11, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Carl Jaffe
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A BerrutiL Dogliotti
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J AlexandreE Cvitkovic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.