A calmodulin-like protein regulates plasmodesmal closure during bacterial immune responses

The New Phytologist
Bo XuMatthew Gilliham

Abstract

Plants sense microbial signatures via activation of pattern recognition receptors (PPRs), which trigger a range of cellular defences. One response is the closure of plasmodesmata, which reduces symplastic connectivity and the capacity for direct molecular exchange between host cells. Plasmodesmal flux is regulated by a variety of environmental cues but the downstream signalling pathways are poorly defined, especially the way in which calcium regulates plasmodesmal closure. Here, we identify that closure of plasmodesmata in response to bacterial flagellin, but not fungal chitin, is mediated by a plasmodesmal-localized Ca2+ -binding protein Calmodulin-like 41 (CML41). CML41 is transcriptionally upregulated by flg22 and facilitates rapid callose deposition at plasmodesmata following flg22 treatment. CML41 acts independently of other defence responses triggered by flg22 perception and reduces bacterial infection. We propose that CML41 enables Ca2+ -signalling specificity during bacterial pathogen attack and is required for a complete defence response against Pseudomonas syringae.

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Citations

Mar 3, 2018·International Journal of Molecular Sciences·Didier AldonJean-Philippe Galaud
Jan 15, 2018·The New Phytologist·Jörg KudlaKarin Schumacher
Oct 31, 2017·The New Phytologist·Cecilia Cheval, Christine Faulkner
Aug 31, 2018·Journal of Experimental Botany·Shu-Wei WuJae-Yean Kim
Apr 12, 2019·Journal of Experimental Botany·Aart J E van Bel, Rita Musetti
Aug 10, 2019·Nature Communications·Keunhwan ParkKaare H Jensen
May 2, 2018·International Journal of Molecular Sciences·Valentina La VerdeAlessandra Astegno
Apr 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Cécilia ChevalChristine Faulkner
Oct 19, 2017·Journal of Experimental Botany·Sam AmsburyYoselin Benitez-Alfonso
May 23, 2018·International Journal of Molecular Sciences·Kjell De VrieseSteffen Vanneste
Dec 29, 2020·Frontiers in Plant Science·Isaac Vega-MuñozSimon Stael
May 8, 2021·Frontiers in Plant Science·Zhongpeng LiKyaw Aung
Jun 22, 2021·Frontiers in Plant Science·Arya Bagus Boedi IswantoSang Hee Kim
Sep 28, 2021·Molecular Plant Pathology·Arya Bagus Boedi IswantoSang Hee Kim
Sep 17, 2021·The Plant Journal : for Cell and Molecular Biology·Qiguo SunZhenfei Guo
Sep 17, 2021·The Plant Cell·Adrienne H K RoederCarlos Messina

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Methods Mentioned

BETA
transgenic
PCR
Fluorescence
electrophoresis
biopsy
microscale thermophoresis

Software Mentioned

Web Micro RNA Designer

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