A Candida auris Outbreak and Its Control in an Intensive Care Setting

The New England Journal of Medicine
David W EyreKatie J M Jeffery

Abstract

Candida auris is an emerging and multidrug-resistant pathogen. Here we report the epidemiology of a hospital outbreak of C. auris colonization and infection. After identification of a cluster of C. auris infections in the neurosciences intensive care unit (ICU) of the Oxford University Hospitals, United Kingdom, we instituted an intensive patient and environmental screening program and package of interventions. Multivariable logistic regression was used to identify predictors of C. auris colonization and infection. Isolates from patients and from the environment were analyzed by whole-genome sequencing. A total of 70 patients were identified as being colonized or infected with C. auris between February 2, 2015, and August 31, 2017; of these patients, 66 (94%) had been admitted to the neurosciences ICU before diagnosis. Invasive C. auris infections developed in 7 patients. When length of stay in the neurosciences ICU and patient vital signs and laboratory results were controlled for, the predictors of C. auris colonization or infection included the use of reusable skin-surface axillary temperature probes (multivariable odds ratio, 6.80; 95% confidence interval [CI], 2.96 to 15.63; P<0.001) and systemic fluconazole exposure (mult...Continue Reading

References

Jul 1, 2011·Journal of Clinical Microbiology·Wee Gyo LeeHee-Chang Jang
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Sep 17, 2016·The Journal of Hospital Infection·A ChowdharyJ F Meis
Oct 26, 2016·Antimicrobial Resistance and Infection Control·Silke SchelenzMatthew C Fisher
Dec 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shawn R LockhartAnastasia P Litvintseva
Jan 31, 2017·Revista iberoamericana de micología·Alba Cecilia Ruiz GaitánJavier Pemán
Feb 17, 2017·Medical Mycology·Andrew M BormanElizabeth M Johnson
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Shivaprakash M RudramurthyAnup Ghosh
Jul 12, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Christina T PiedrahitaCurtis J Donskey
Aug 11, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jennifer L CadnumCurtis J Donskey

❮ Previous
Next ❯

Citations

Dec 6, 2018·Acta Clinica Belgica·Klaas DewaeleKatrien Lagrou
Dec 27, 2018·Mycoses·Mahdi AbastabarHamid Badali
Feb 28, 2019·The New England Journal of Medicine·David W EyreKatie J M Jeffery
Feb 6, 2019·Antimicrobial Agents and Chemotherapy·Jeffrey M RybakP David Rogers
Apr 9, 2019·PLoS Pathogens·Jeniel E Nett
Jun 11, 2019·Emerging Microbes & Infections·Scott C RobertsBabafemi O Taiwo
Feb 19, 2019·Mycoses·Shabir A Lone, Aijaz Ahmad
Jun 25, 2019·The Medical Journal of Australia·Deborah A WilliamsonDavid L Paterson
Jul 30, 2019·Annals of Internal Medicine·Snigdha VallabhaneniTom M Chiller
Aug 11, 2019·Mycopathologia·Micheál Mac AogáinSanjay H Chotirmall
Oct 9, 2019·Current Opinion in Infectious Diseases·Gabriela Corsi-Vasquez, Luis Ostrosky-Zeichner
Oct 28, 2019·Journal of Fungi·Amal Al MaaniAbdullah M S Al-Hatmi
Sep 21, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Vijeta BajpaiPurva Mathur
Jan 31, 2020·Journal of Clinical Microbiology·Brian L Wickes
Mar 1, 2020·Journal of Fungi·Ryan KeanGordon Ramage
Apr 3, 2020·Expert Review of Anti-infective Therapy·Arunaloke Chakrabarti, Shreya Singh
May 3, 2019·Critical Care : the Official Journal of the Critical Care Forum·Andrea CortegianiDavid Eyre
May 25, 2020·The Medical Journal of Australia·Leon J WorthMonica A Slavin
May 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ahmed S SultanMary Ann Jabra-Rizk
Jul 10, 2020·Journal of Fungi·Iris CampBirgit Willinger
Jul 17, 2020·Journal of Paediatrics and Child Health·Jayasree ChandramatiSasidharan Ponthenkandath
Jul 10, 2020·Pathogens and Disease·Taissa VilaMary Ann Jabra-Rizk
Jul 31, 2020·PLoS Pathogens·Andrew M Borman, Elizabeth M Johnson
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ahmed BabikerMary K Hayden
Sep 30, 2020·Intensive Care Medicine·C LoganT Bicanic
Oct 1, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Manish ThakurCurtis J Donskey
Sep 5, 2019·Frontiers in Microbiology·Milena Kordalewska, David S Perlin
Aug 20, 2019·Internal Medicine Journal·Chong W OngUNKNOWN Australian and New Zealand Mycoses Interest Group (ANZMIG); and the Healthcare Infection Control Special Interest Group (HIC
Oct 19, 2019·Journal of Fungi·Colin S Brown, Rebecca Guy
Dec 19, 2019·Frontiers in Microbiology·Farid ChaabaneAlix T Coste
Jun 12, 2020·Antimicrobial Resistance and Infection Control·Hector Felipe Garcia-JeldesAmrita Bharat
Jun 9, 2020·Frontiers in Microbiology·Fruzsina NagyRenátó Kovács

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Sharon TsaySnigdha Vallabhaneni
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
David Sears, Brian S Schwartz
© 2021 Meta ULC. All rights reserved