A canine hybrid double-bundle model for study of arthroscopic ACL reconstruction

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
James L CookCristi R Cook

Abstract

Development and validation of a large animal model for pre-clinical studies of intra-articular anterior cruciate ligament (ACL) reconstruction that addresses current limitations is highly desirable. The objective of the present study was to investigate a translational canine model for ACL reconstruction. With institutional approval, adult research hounds underwent arthroscopic debridement of the anteromedial bundle (AMB) of the ACL, and then either received a tendon autograft for "hybrid double-bundle" ACL reconstruction (n = 12) or no graft to remain ACL/AMB-deficient (n = 6). Contralateral knees were used as non-operated controls (n = 18) and matched canine cadaveric knees were used as biomechanical controls (n = 6). Dogs were assessed using functional, diagnostic imaging, gross, biomechanical, and histologic outcome measures required for pre-clinical animal models. The data suggest that this canine model was able to overcome the major limitations of large animal models used for translational research in ACL reconstruction and closely follow clinical aspects of human ACL reconstruction. The "hybrid double-bundle" ACL reconstruction allowed for sustained knee function without the development of osteoarthritis and for significa...Continue Reading

References

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Citations

Feb 9, 2016·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Patrick A SmithJames L Cook
Aug 3, 2020·Sports Medicine and Arthroscopy Review·James P StannardJames L Cook
Dec 2, 2020·The American Journal of Sports Medicine·Sebastian Cardona-RamirezRichard Ma
Oct 17, 2020·Stem Cells International·Yan XuCan Chen
Mar 31, 2019·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Patrick A SmithJames L Cook

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