PMID: 2495318May 1, 1989Paper

A canine model of coronary artery thrombosis with superimposed high grade stenosis for the investigation of rethrombosis after thrombolysis

Journal of the American College of Cardiology
T YasudaD Collen

Abstract

A canine model was developed to investigate coronary artery thrombolysis and reocclusion in the setting of endothelial cell damage and fixed stenosis, which simulate anatomic features occurring in patients with acute myocardial infarction. In open chest dogs, endothelial cell damage was produced in the left anterior descending coronary artery by external compression with blunt forceps, greater than 90% stenosis was obtained by an external constrictor and thrombosis was induced by instillation of thrombin and fresh blood in an isolated arterial segment. In the absence of stenosis, intravenous infusion of 750,000 U of streptokinase over 1 h caused reperfusion in five of six dogs in 34 +/- 25 min (mean +/- SD). Urokinase, 600,000 U intravenously over 30 min followed by 600,000 U over 30 min by the intracoronary route, induced reperfusion in three of four dogs in 65 +/- 23 min. Recombinant two chain tissue-type plasminogen activator (rt-PA) (G11021), infused intravenously at a rate of 15 micrograms/kg per min for 30 min or until reflow, induced reperfusion in all 12 dogs in 28 +/- 13 min. In the absence of coronary artery stenosis, spontaneous reocclusion did not occur within 2 h after the end of the infusion. In the presence of th...Continue Reading

References

Jun 15, 1984·The American Journal of Cardiology·H K GoldR C Leinbach

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Citations

Oct 1, 1993·Catheterization and Cardiovascular Diagnosis·T A DewhurstJ L Ritchie
Sep 1, 1990·Journal of the American College of Cardiology·J H Chesebro, V Fuster
Apr 1, 1997·The Journal of Clinical Investigation·C A LawsonD J Pinsky
Sep 28, 2010·Journal of Neurosurgery·Muhammad Zeeshan MemonElad I Levy
May 1, 2002·Techniques in Vascular and Interventional Radiology·K Ouriel
Jan 1, 1990·Thrombosis Research. Supplement·T Yasuda, H K Gold
May 1, 1992·Progress in Cardiovascular Diseases·J FareedR Pifarre
Aug 15, 1991·Archives of Biochemistry and Biophysics·L IulianoF Violi
Sep 1, 1991·Progress in Cardiovascular Diseases·D CollenH K Gold

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