A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients

The American Journal on Addictions
Romain IcickFlorence Vorspan

Abstract

The burden of opiate dependence not only relies on somatic complications such as infectious diseases or acute intoxication but also on frequent psychiatric events such as major depressive disorder (MDD) and suicidal behavior (SB). Given the preclinical and clinical evidence regarding the associations between cannabinoid systems and both opiate dependence and psychiatric disorders, we chose to address whether one single nucleotide polymorphism (SNP) of the cannabinoid receptor type 1 gene (CNR1) named rs2023239 would be associated with lifetime MDD and SB in a population of opiate-dependent outpatients remitted under stable methadone treatment. Sociodemographic and clinical data were included as independent factors in two logistic regression models aimed at predicting SB and MDD, respectively, performed with 85 Caucasian individuals. The minor C allele of rs2023239 showed an independent protective effect against lifetime MDD after adjustment for potential confounders. It was not associated with variables related to suicidal behavior. Despite limitations due to the modest sample size, our results are consistent with previous research on the endocannabinoid system and suggest new leads for detecting subjects at risk of MDD, which ...Continue Reading

References

Jul 13, 1999·Archives of General Psychiatry·R C KesslerE E Walters
Aug 17, 1999·European Archives of Psychiatry and Clinical Neuroscience·M PreisigF Ferrero
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Nov 2, 2002·Addiction·Shane Darke, Joanne Ross
May 20, 2003·Addiction·Zhiwei ZhangDean R Gerstein
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Nov 5, 2003·Nature Reviews. Neuroscience·Daniele Piomelli
Feb 12, 2005·Biological Psychiatry·Andrea PfennigElisabeth B Binder
Jun 3, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aryeh I HermanJonathan Covault
May 17, 2008·Addiction Biology·Patricia RobledoRafael Maldonado
Jul 9, 2008·Archives of General Psychiatry·Xiangning ChenKenneth S Kendler
Jul 9, 2008·Archives of General Psychiatry·Kent E HutchisonFrancesca Filbey
Nov 20, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Arpana AgrawalTatiana Foroud
Feb 4, 2010·Journal of Psychiatric Research·James M BoltonJitender Sareen
Mar 3, 2010·Addiction Biology·Amine BenyaminaMarie-Odile Krebs
Mar 10, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Fabrice JollantPhilippe Courtet
Oct 4, 2011·Annual Review of Pharmacology and Toxicology·Nora D VolkowDardo Tomasi
Nov 17, 2011·Alcoholism, Clinical and Experimental Research·Miguel MarcosRogelio González-Sarmiento
Mar 7, 2012·Archives of General Psychiatry·Arpana AgrawalMichael T Lynskey
Apr 3, 2012·Acta Physiologica·E KirillyG Bagdy
Jun 7, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph P SchachtFrancesca M Filbey
Apr 23, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michel Hamon, Pierre Blier
Jul 25, 2013·Journal of Psychiatric Research·Ding-Lieh LiaoJoseph J S Cheng
Jul 28, 2013·Neuroscience and Biobehavioral Reviews·Laura Mandelli, Alessandro Serretti
Nov 16, 2013·The Journal of Clinical Investigation·Sarah Ann R AndersonYasmin L Hurd
Nov 16, 2013·Neuropsychiatric Disease and Treatment·Marta SadkowskiZainab Samaan
Jun 24, 2014·Brain, Behavior, and Immunity·Molly S CroweSteven G Kinsey
Aug 21, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Einat PelesMiriam Adelson
Aug 27, 2014·Journal of Affective Disorders·Kathryn Elizabeth CairnsAnthony Francis Jorm
Oct 8, 2014·Journal of Psychiatric Research·Justine M GattPeter R Schofield
May 20, 2015·Molecular Psychiatry·N HoertelC Blanco

❮ Previous
Next ❯

Citations

Aug 27, 2019·Journal of Behavioral Addictions·Arundhuti DasCsaba Barta
May 13, 2020·Frontiers in Psychiatry·Francisco NavarreteJorge Manzanares
Mar 17, 2018·Current Psychiatry Reports·Laura ColinoHilario Blasco-Fontecilla
Feb 17, 2021·The Pharmacogenomics Journal·David BrightMinji Sohn
Dec 27, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrea Locci, Graziano Pinna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.