A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats.

British Journal of Pharmacology
A ZakrzeskaB Malinowska

Abstract

Intravenous injection of the endocannabinoid anandamide induces complex cardiovascular changes via cannabinoid CB(1), CB(2) and vanilloid TRPV1 receptors. Recently, evidence has been accumulating that in vitro, but not in vivo, anandamide relaxes blood vessels, via an as yet unidentified, non-CB(1) vascular cannabinoid receptor, sensitive to O-1918 (1,3-dimethoxy-5-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-benzene). We here examined whether the anandamide-induced hypotension in urethane-anaesthetized rats was also mediated via a non-CB(1) vascular cannabinoid receptor. Effects of two antagonists (O-1918 and cannabidiol) of the non-CB(1) vascular cannabinoid receptor on anandamide-induced changes in mean, systolic and diastolic blood pressure (MBP, SBP, DBP), mesenteric (MBF) and renal (RBF) blood flow and heart rate (HR) in urethane-anaesthetized rats was examined. In anaesthetized rats, anandamide (1.5-3 micromol.kg(-1)) and its stable analogue methanandamide (0.5 micromol.kg(-1)) caused a delayed and prolonged decrease in MBP, SBP, DBP, MBF and RBF by about 10-30% of the respective basal values without changing HR. In pithed rats, anandamide (3 micromol.kg(-1)) decreased blood pressure by about 15-20% of the ...Continue Reading

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Citations

Mar 4, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·B MalinowskaE Schlicker
Jul 21, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anna-Maria SzczesniakMelanie E M Kelly
May 26, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marta Baranowska-KuczkoBarbara Malinowska
Oct 26, 2011·British Journal of Pharmacology·Barbara MalinowskaEberhard Schlicker
Jul 31, 2014·British Journal of Pharmacology·Alexander I Bondarenko
Apr 3, 2012·European Journal of Pharmacology·Jamie J HoppsMichael D Randall
Aug 5, 2011·Channels·Cadie L Buckley, Alexander J Stokes
Apr 23, 2014·European Journal of Pharmacology·Jessica MacIntyreMelanie E M Kelly
May 17, 2018·Therapeutic Advances in Cardiovascular Disease·Virna Margarita Martín GiménezWalter Manucha
Jul 28, 2017·American Journal of Physiology. Renal Physiology·Frank ParkCsaba P Kovesdy
Jul 28, 2019·Cannabis and Cannabinoid Research·Janice T ChuaHamid Moradi
Nov 17, 2020·Oxidative Medicine and Cellular Longevity·J A Garza-CervantesG García-Rivas
Apr 6, 2020·Journal of Vascular Research·Bruno A Marichal-CancinoCarlos M Villalón

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