A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol)

Toxicological Sciences : an Official Journal of the Society of Toxicology
Gaëtan PhilippotHenrik Viberg

Abstract

Acetaminophen (AAP; also known as paracetamol) is the most used and only recommended analgesic and antipyretic among pregnant women and young children. However, recent findings in both humans and rodents suggest a link between developmental exposure to AAP and adverse neurobehavioral effects later in life. We hypothesized that the cannabinoid receptor type 1 (CB1R) may be involved in the developmental neurotoxicity of AAP, owing to its interaction with the endocannabinoid system. Here we test if CB1R agonist WIN 55 212-2 (WIN) and AAP can interact when exposure occurs during a neurodevelopmental stage known for increased growth rate and for its vulnerability to AAP exposure. We exposed male NMRI mice on postnatal day 10 to different combinations of AAP and WIN. Adult mice, neonatally co-exposed to AAP and WIN, displayed a significant lack of habituation in the spontaneous behavior test, when compared with controls and single agent exposed mice. These adult adverse effects may at least in part be explained by a reduction of transcript levels of hippocampal synaptophysin (Syp) and tropomyosin receptor kinase B (Trkb), and cerebral cortical fatty acid amide hydroxylase (Faah), 24 h after exposure. These findings are consistent wit...Continue Reading

References

Mar 1, 1979·Early Human Development·J Dobbing, J Sands
Sep 1, 1970·Psychological Review·P M Groves, R F Thompson
Dec 16, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·J V LavigneR D Gibbons
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·B F CravattA H Lichtman
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 5, 2003·Annual Review of Biochemistry·Eric J Huang, Louis F Reichardt
Apr 29, 2004·Nature Neuroscience·Laurence H Tecott, Eric J Nestler
Jul 23, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tania AguadoIsmael Galve-Roperh
Dec 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Paul BerghuisTibor Harkany
May 18, 2006·Reviews in the Neurosciences·Colin LeverJohn O'Keefe
Jan 18, 2007·CNS Drug Reviews·Alfio BertoliniSheila Leone
May 26, 2007·Science·Paul BerghuisTibor Harkany
Jul 5, 2007·Journal of Paediatrics and Child Health·Anne WalshJenny Fraser
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Sep 25, 2008·PloS One·Philip Barnes, Kerrie L Thomas
Apr 16, 2013·Progress in Neurobiology·Bridgette D SempleLinda J Noble-Haeusslein
Oct 29, 2013·International Journal of Epidemiology·Ragnhild Eek BrandlistuenHedvig Nordeng
Dec 24, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Henrik VibergAnders Fredriksson
Apr 9, 2015·Developmental Medicine and Child Neurology·Laurence de FaysBernard Dan
Sep 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kamilla Blecharz-KlinEwa Widy-Tyszkiewicz
Dec 22, 2015·Environmental Toxicology and Pharmacology·Stefan Hallgren, Henrik Viberg
Apr 26, 2016·Anesthesiology and Pain Medicine·Shun MuramatsuYasuhito Uezono
Sep 10, 2016·Pharmacological Reports : PR·Kamilla Blecharz-KlinEwa Widy-Tyszkiewicz
Feb 7, 2017·Behavioural Brain Research·Kamilla Blecharz-KlinEwa Widy-Tyszkiewicz
Jan 18, 2018·Hormones and Behavior·Ann Z BauerShanna H Swan

❮ Previous
Next ❯

Citations

Nov 23, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gaëtan PhilippotRobert Fredriksson
Mar 11, 2020·Neonatology·John N van den Anker, Karel Allegaert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.