A carboxy-terminal peptide of the alpha 1-subunit of the dihydropyridine receptor inhibits Ca(2+)-release channels

The American Journal of Physiology
K J SlavikS L Hamilton

Abstract

Excitation-contraction coupling in skeletal muscle is thought to involve a physical interaction between the alpha 1-subunit of the dihydropyridine receptor (DHPR) and the sarcoplasmic reticulum (SR) Ca(2+)-release channel (also known as the ryanodine receptor). Considerable evidence has accumulated to suggest that the cytoplasmic loop between domains II and III of the DHPR alpha 1-subunit is at least partially responsible for this interaction. Other parts of this subunit or other subunits may, however, contribute to the functional and/or structural coupling between these two proteins. A synthetic peptide corresponding to a conserved sequence located between amino acids 1487 and 1506 in the carboxy terminus of the alpha 1-subunit inhibits both [3H]ryanodine binding to skeletal and cardiac SR membranes and the activity of skeletal SR Ca(2+)-release channels reconstituted into planar lipid bilayers. A second, multiantigenic peptide synthesized to correspond to the same sequence inhibits both binding and channel activity at lower concentrations than the linear peptide. These peptides slow the rate at which [3H]ryanodine binds to its high-affinity binding site and decrease the rate at which [3H]ryanodine dissociates from this site. ...Continue Reading

References

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Citations

Sep 26, 2000·American Journal of Physiology. Cell Physiology·G D LambD G Stephenson
Oct 5, 2002·The Journal of Biological Chemistry·Rao V L PapineniSusan L Hamilton
Sep 28, 2007·Journal of Muscle Research and Cell Motility·Roger A Bannister
Dec 16, 2003·Journal of Applied Physiology·Christopher P IngallsR B Armstrong
Dec 22, 1999·Annals of the New York Academy of Sciences·D M BersE McCall
Dec 1, 2001·The Journal of Biological Chemistry·Catherine ProenzaKurt G Beam
Sep 25, 2002·Physiological Reviews·Michael Fill, Julio A Copello
Jul 29, 2004·The Journal of Biological Chemistry·Nancy M LorenzonKurt G Beam
Jan 11, 2005·The Journal of Biological Chemistry·George G RodneyMartin F Schneider
Aug 14, 2001·The Journal of Biological Chemistry·S SencerS L Hamilton
Sep 13, 2002·Progress in Biophysics and Molecular Biology·A F DulhuntyM G Casarotto
Apr 29, 1998·Trends in Neurosciences·D Walker, M De Waard
Jan 27, 2004·Biochemical and Biophysical Research Communications·Mark L BannisterRebecca Sitsapesan
Jun 18, 2010·Progress in Biophysics and Molecular Biology·Eun Hui Lee

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