A carcinogenesis reversibility study of the effects of butylated hydroxyanisole on the forestomach and urinary bladder in male Fischer 344 rats

Toxicology
E A NeraD B Clayson

Abstract

A reversibility study was initiated to determine if the length of feeding with 2% butylated hydroxyanisole (BHA) altered the incidence of forestomach lesions observed after a 24-month observation period. Groups of male Fischer 344 rats were fed 2% BHA for 0, 3, 6, 12, and 24 months and then the basal diet for the completion of the 24-month experimental period. Subgroups were serially sacrificed for histopathological examination and [methyl-3H]thymidine radioautography at the time when each group of animals was transferred to the basal diet and also at 15 months. The results showed that except for carcinomas and some epithelial downgrowths, cellular proliferation, measured by radioautography in the epithelium lining the greater and the lesser curvature of the forestomach, remained dependent on the continuous presence of 2% BHA for, at least, 12 months. Superficial hyperplasias, inflammatory lesions and many of the papillomas regressed after cessation of treatment at 12 months. The epithelial downgrowths did not appear to enlarge after the BHA was withdrawn. The squamous cell carcinomas occurred in almost identical yields whether the rats were fed 2% BHA for 12 months and then returned to the basal diet for 12 months or received ...Continue Reading

References

Mar 1, 1975·Toxicology and Applied Pharmacology·S S Mirvish
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M Williams
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N ItoM Tatematsu
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F IversonJ Wong
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M TobeJ Kanno
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G Würtzen, P Olsen
Feb 1, 1985·Cancer Letters·F IversonD B Clayson
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD

❮ Previous
Next ❯

Citations

Dec 7, 2006·Cell Biology and Toxicology·V LabradorM J Hazen
Dec 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M WilliamsM J Iatropoulos
Feb 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P A SchildermanJ C Kleinjans
Apr 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P T Harrison
Feb 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P A SchildermanJ C Kleinjans
Mar 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J WhysnerG M Williams
Mar 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R MongeauD B Clayson
Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D B ClaysonS M Cohen
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F Iverson
Dec 1, 1993·Environmental Health Perspectives·B I GhanayemH B Matthews
Feb 1, 1989·Regulatory Toxicology and Pharmacology : RTP·D KrewskiD Murdoch
Jan 1, 1991·Chemico-biological Interactions·H VerhagenJ C Kleinjans
Nov 1, 1993·Japanese Journal of Cancer Research : Gann·M KagawaM Hirose
Jun 1, 1990·Japanese Journal of Cancer Research : Gann·A NyskaB Klein
Mar 1, 1994·Toxicologic Pathology·J S MacDonaldR E Morrissey
Apr 1, 1993·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·R Kahl, H Kappus
Jan 2, 1994·International Journal of Cancer. Journal International Du Cancer·E AsakawaN Ito
Jan 1, 1993·Toxicology and Industrial Health·J Whysner
Jan 1, 1993·Toxicology and Industrial Health·D B ClaysonE Lok
Feb 9, 2021·Regulatory Toxicology and Pharmacology : RTP·Susan P FelterChad Thompson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D B ClaysonK Karpinski
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
G Würtzen, P Olsen
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
H J AltmannC A van der Heijden
© 2021 Meta ULC. All rights reserved