A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function

Proceedings of the National Academy of Sciences of the United States of America
Frank J GiordanoNapoleone Ferrara

Abstract

The role of the cardiac myocyte as a mediator of paracrine signaling in the heart has remained unclear. To address this issue, we generated mice with cardiac myocyte-specific deletion of the vascular endothelial growth factor gene, thereby producing a cardiomyocyte-specific knockout of a secreted factor. The hearts of these mice had fewer coronary microvessels, thinned ventricular walls, depressed basal contractile function, induction of hypoxia-responsive genes involved in energy metabolism, and an abnormal response to beta-adrenergic stimulation. These findings establish the critical importance of cardiac myocyte-derived vascular endothelial growth factor in cardiac morphogenesis and determination of heart function. Further, they establish an adult murine model of hypovascular nonnecrotic cardiac contractile dysfunction.

References

Oct 1, 1992·Journal of Applied Physiology·R KacimiB Crozatier
Dec 1, 1991·Cell Regulation·C S LongP C Simpson
Oct 1, 1991·The Journal of Investigative Dermatology·V FalangaM B Sporn
Jul 10, 1985·The American Journal of Cardiology·W W Parmley
Feb 1, 1973·The American Journal of Cardiology·R Zak
Oct 1, 1994·The Journal of Clinical Investigation·N TakahashiW S Colucci
Jul 1, 1996·Journal of Vascular Research·O Hudlicka, M D Brown
Aug 1, 1996·The Journal of Clinical Investigation·K RajewskyF Schwenk
Oct 1, 1996·Genome Research·U E GibsonP M Williams
Nov 1, 1996·Progress in Cardiovascular Diseases·A M ShahW J Paulus
Oct 28, 1998·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·M J EppihimerD N Granger
Oct 28, 1998·Physiological Reviews·G Heusch
Oct 29, 1998·The Journal of Biological Chemistry·B Q ShenT F Zioncheck
Apr 28, 1999·FEBS Letters·M NishimuraS Seino

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Citations

Oct 13, 2001·Journal of Magnetic Resonance Imaging : JMRI·S P WilliamsN van Bruggen
Mar 24, 2007·Cellular and Molecular Life Sciences : CMLS·A A FilipczykC L Mummery
Sep 22, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Keiji KubaJosef M Penninger
Mar 3, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jincai LuoYao Lu
May 29, 2009·Cytotechnology·Laurel S RodgersTodd D Camenisch
Aug 10, 2011·Current Hypertension Reports·Colin F GreinederBonnie Ky
Nov 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·David A BullSun Wan Kim
Jul 13, 2005·Progress in Biophysics and Molecular Biology·Shant Der SarkissianMohan K Raizada
Dec 5, 2000·Current Opinion in Biotechnology·N Ferrara
Apr 15, 2003·Trends in Cardiovascular Medicine·Gavin Y OuditJosef M Penninger
Aug 6, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J Dawn Abbott, Frank J Giordano
May 19, 2012·Nature·Ian S PattenZoltan Arany
Jul 8, 2009·Nature Reviews. Clinical Oncology·Helen X Chen, Jessica N Cleck
Dec 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dalit MayEli Keshet
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Min ZhangAjay M Shah
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Filio BilliaTak W Mak
Oct 16, 2009·The Journal of Biological Chemistry·Yasumasa IkedaKenneth Walsh
Jul 14, 2007·Antioxidants & Redox Signaling·Steven A Fisher, Warren W Burggren
Feb 25, 2011·Cardiovascular Research·Jun-Ming TangShi-You Chen
Dec 20, 2011·Cardiovascular Research·Anke J TijsenEsther E Creemers
Apr 17, 2012·European Heart Journal·Simon T MacDonaldShoumo Bhattacharya
Oct 16, 2004·Neuroreport·Rustem R IslamovAlexander K Murashov
Feb 8, 2006·Annual Review of Physiology·Patrick C H HsiehRichard T Lee
Sep 18, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David ZisaTechung Lee
May 17, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun SuKhalid Matrougui
Jun 4, 2011·Circulation Research·Federica AccorneroJeffery D Molkentin
Sep 2, 2010·Circulation·Daniela TirziuMichael Simons
Feb 4, 2005·The Journal of Clinical Investigation·Young-sup YoonDouglas W Losordo
Mar 15, 2005·The Journal of Clinical Investigation·Frank J Giordano

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